| 1 | F2RL3, GRK5
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| A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling
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| Rodriguez BAT, Bhan A, Beswick A, Elwood PC, Niiranen TJ, Salomaa V; FinnGen Study, Trégouët DA, Morange PE, Civelek M, Ben-Shlomo Y, Schlaeger T, Chen MH, Johnson AD.
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| Am J Hum Genet. Aug 6;107(2):211-221. doi: 10.1016/j.ajhg.2020.06.008. Epub 2020 Jul 9 2020
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| 2 | F2RL3, PCTP
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| Identification of a functional genetic variant driving racially dimorphic platelet gene expression of the thrombin receptor regulator, PCTP.
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| Kong X, Simon LM, Holinstat M, Shaw CA, Bray PF, Edelstein LC.
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| Thromb Haemost hromb Haemost. 2017 Mar 2. doi: 10.1160/TH16-09-0692. [Epub ahead of print]
2017
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| 3 | F2RL3, KLK1
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| Tissue kallikrein mediates pro-inflammatory pathways and activation of protease-activated receptor-4 in proximal tubular epithelial cells.
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| Yiu WH, Wong DW, Chan LY, Leung JC, Chan KW, Lan HY, Lai KN, Tang SC.
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| PLoS One 9(2):e88894. doi: 10.1371/journal.pone.0088894. eCollection 2014.
2014
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| 4 | F2R, F2RL3
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| Mapping human protease-activated receptor 4 (PAR4) homodimer interface to transmembrane helix 4.
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| de la Fuente M, Noble DN, Verma S, Nieman MT.
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| J Biol Chem 287(13):10414-23. doi: 10.1074/jbc.M112.341438. Epub 2012 Feb 8.
2012
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| 5 | F2RL3
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| Decreased expression of protease-activated receptor 4 in human gastric cancer.
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| Zhang Y, Yu G, Jiang P, Xiang Y, Li W, Lee W, Zhang Y.
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| Int J Biochem Cell Biol 43(9):1277-83. doi: 10.1016/j.biocel.2011.05.008. Epub 2011 May 25.
2011
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| 6 | F2RL3, TFF2
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| Activation of protease-activated receptor (PAR) 1 by frog trefoil factor (TFF) 2 and PAR4 by human TFF2.
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| Zhang Y, Yu G, Wang Y, Xiang Y, Gao Q, Jiang P, Zhang J, Lee W, Zhang Y.
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| Cell Mol Life Sci 68(22):3771-80. doi: 10.1007/s00018-011-0678-6. Epub 2011 Apr 3.
2011
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| 7 | F2R, F2RL3
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| Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones.
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| Vellani V, Kinsey AM, Prandini M, Hechtfischer SC, Reeh P, Magherini PC, Giacomoni C, McNaughton PA.
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| Mol Pain 6:61. doi: 10.1186/1744-8069-6-61.
2010
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| 8 | F2RL3
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| Deficiency of PAR4 attenuates cerebral ischemia/reperfusion injury in mice.
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| Mao Y, Zhang M, Tuma RF, Kunapuli SP.
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| J Cereb Blood Flow Metab 30(5):1044-52. doi: 10.1038/jcbfm.2009.283. Epub 2010 Jan 20. Erratum in: J Cereb Blood Flow Metab. 2010 Jun;30(6):1261.
2010
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| 9 | F2RL3, MASP1
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| Complement protease MASP-1 activates human endothelial cells: PAR4 activation is a link between complement and endothelial function.
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| Megyeri M, Makó V, Beinrohr L, Doleschall Z, Prohászka Z, Cervenak L, Závodszky P, Gál P.
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| J Immunol 183(5):3409-16. doi: 10.4049/jimmunol.0900879. Epub 2009 Aug 10.
2009
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| 10 | F2RL3
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| Regulation of plasmin-induced protease-activated receptor 4 activation in platelets.
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| Mao Y, Jin J, Daniel JL, Kunapuli SP.
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| Platelets 20(3):191-8. doi: 10.1080/09537100902803635.
2009
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| 11 | F2RL3
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| Protease-activated receptor-4 (PAR 4): a role as inhibitor of visceral pain and hypersensitivity.
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| Augé C, Balz-Hara D, Steinhoff M, Vergnolle N, Cenac N.
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| Neurogastroenterol Motil 21(11):1189-e107. doi: 10.1111/j.1365-2982.2009.01310.x. Epub 2009 Apr 20.
2009
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| 12 | F2RL3
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| Protease-activated receptor 4 uses anionic residues to interact with alpha-thrombin in the absence or presence of protease-activated receptor 1.
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| Nieman MT.
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| Biochemistry 47(50):13279-86. doi: 10.1021/bi801334s.
2008
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| 13 | F2RL3
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| Essential role of platelet activation via protease activated receptor 4 in tissue factor-initiated inflammation.
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| Busso N, Chobaz-Péclat V, Hamilton J, Spee P, Wagtmann N, So A.
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| Arthritis Res Ther 10(2):R42. doi: 10.1186/ar2400. Epub 2008 Apr 15.
2008
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| 14 | F2RL3
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| PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation.
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| Holinstat M, Voss B, Bilodeau ML, McLaughlin JN, Cleator J, Hamm HE.
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| J Biol Chem 281(36):26665-74. Epub 2006 Jul 12. 2006
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| 15 | F2RL3
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| Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP.
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| Adam F, Verbeuren TJ, Fauchere JL, Guillin MC, Jandrot-Perrus M.
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| J Thromb Haemost 1(4):798-804. 2003
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| 16 | CTSG, F2RL3
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| Cathepsin G activates protease-activated receptor-4 in human platelets.
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| Sambrano GR, Huang W, Faruqi T, Mahrus S, Craik C, Coughlin SR.
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| J Biol Chem 275(10):6819-23. 2000
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| 17 | F2RL2, F2RL3
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| PAR3 is a cofactor for PAR4 activation by thrombin.
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| Nakanishi-Matsui M, Zheng YW, Sulciner DJ, Weiss EJ, Ludeman MJ, Coughlin SR.
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| Nature 404(6778):609-13. 2000
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| 18 | F2R, F2RL3
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| Cloning and characterization of human protease-activated receptor 4.
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| Xu W, et al.
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| Proc Natl Acad Sci U S A 95 : 6642-6646. 1998
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