SUBCELLULAR LOCALIZATION
| extracellular
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,cytosolic,ribosome
|
| intracellular,nucleus,nucleolus
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text
| endogenous, newly synthesized RPL5 and RPL11 continue to be imported into nucleoli even after nucleolar disruption and colocalize with MDM2, TP53, and promyelocytic leukemia protein |
basic FUNCTION
| intracellular 5S RNA transport factor, nucleocytoplasmic trafficking |
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nucleocytoplasmic shuttle protein that plays an important role in 5S rRNA intracellular transport during assembly of the large ribosomal subunit |
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RPL5 and RPL11 were required for rRNA export from the nucleolus |
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unlike other tumor suppressors, RPL5/RPL11 play an essential role in normal cell proliferation, a function cells have evolved to rely on in lieu of a cell cycle checkpoint (pMID: 24061479) |
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RPL5, co-operatively with RPL11, guides the RNA-induced silencing complex (RISC) to MYC mRNA and mediates the degradation of the mRNA, consequently leading to inhibition of MYC activity |
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RPL5, and RPL11 can co-operatively suppress MYC expression, allowing a tightly controlled ribosome biogenesis in cells |
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RPL5 and RPL11 can enhance the transcriptional activity of a TP53 homolog TP73, but through a distinct mechanism |