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FLASH GENE

Symbol

ETS1

contributors: mct - updated : 18-05-2015

HGNC name	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
HGNC id	3488

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

HLHS2 , DEL11QD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion translocation     translocated t(11;19) (q23;p13) in ALL, fused with EWSR1 tumoral     --over   in both primary breast cancers and breast cancer cell lines, in progression and with metastasis tumoral     --other   deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma

Susceptibility

systemic lupus erythematous

Variant & Polymorphism SNP	3' UTR polymorphism associated with systemic erythematous (SLE), allele 1 with discoid lesions, allele 7 with vasculitis

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive breast target in breast cancer therapy, in cooperation with ERBB2 and MMP1

ANIMAL & CELL MODELS

	homozygous Ets1 deletion mice had large membranous ventricular septal defects, abnormal-appearing left ventricular morphology, characterized by a bifid cardiac apex, and non-apex-forming left ventricle
	Ets1-deficient mice develop a lupus-like disease characterized by high titers of immunoglobulin M (IgM) and IgG autoantibodies and immune-complex deposition in the kidneys