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FLASH GENE
Symbol JAG2 contributors: mct/pgu - updated : 19-05-2021
HGNC name jagged 2
HGNC id 6189
Corresponding disease
LGMDR27 muscular dystrophy, limb-girdle, autosomal recessive 27
Location 14q32.33      Physical location : 105.608.076 - 105.635.161
Synonym symbol(s) HJ2, SER2
DNA
TYPE functioning gene
STRUCTURE 27.09 kb     26 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
26 - 5077 - 1238 - 2011 21372153
  • isoform a
  • 25 - 4963 129.3 1200 - 2011 21372153
  • isoform b
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiens
    Endocrinepancreas   highly Homo sapiens
    Nervousnerve   highly
    Reproductivefemale systembreastmammary gland highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Muscularstriatumskeletal highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
     digestive
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text highly in embryonic limb buds, first branchial arch, developing cochlea and the organ of Corti, central and peripheral nervous system, retina, tooth buds, thymus, submandilas gland, stomach
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • a DSL (Delta, Serrate, Lag2) domain
  • 16 EGF-like repeats
  • a cysteine-rich extracellular region
  • isoforms Precursor
    HOMOLOGY
    interspecies homolog to rattus Jag2
    homolog to Drosophila serrate Dress30
    homolog to murine
    Homologene
    FAMILY Notch ligand family
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • overexpression may be an early event in the pathogenesis of multiple myeloma involving IL6 production
  • play dual roles as activators of Notch receptor signaling and as receptors that mediate nuclear signaling events via gamma-secretase-generated cytoplasmic domain
  • critical role for JAG2-Notch signaling in the maintenance of proliferating neural precursors in a discrete compartment of the neural tube during the continuing growth and development of the vertebrate nervous system
  • JAG2-Notch axis plays a crucial role in dendritic cells-mediated NK cell cytotoxicity
  • can regulate the expression of cytokines that can promote antitumor immunity
  • its expression by dendritic cells is not sufficient or required for Th2 cell differentiation
  • IRF6 and the Notch ligand JAG2 function in convergent molecular pathways during oral epithelial differentiation
  • like Delta-like ligands, induces T-lineage differentiation and inhibits B-cell and myeloid development
  • unexpected functional similarity between JAG2 and the Delta-like ligands
  • hypoxic induction of JAG2 in tumor cells mediates a hypoxia-regulated cross-talk between tumor and endothelial cells
  • JAG2 is a key regulator of the timely and ordered generation of two of the defining cell types in the spinal cord, motor neurons (MNs) and oligodendrocyte progenitors (OLPs)
  • enhances immunomodulatory activity in adipose derived mesenchymal stem cells
  • JAG2 implicated in promoting aggressiveness of colorectal cancer (CRC)
  • JAG2 is involved in the regulation of migration and invasion of colon cancer cells without affecting cell proliferation
  • involved in the regulation of migration and invasion independent of the canonical NoTCH1 signaling pathway
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text inner ear
    PATHWAY
    metabolism
    signaling sensory transduction/hearing
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for NOTCH1 (acts synergistically with DLL1, to regulate hair cell development in the mammalian inner ear)
  • interacting with IRF6 (IRF6 and JAG2 function in convergent molecular pathways during development of the oral ectoderm)
  • weaker NOTCH1-activator compared with the Delta-like ligands, revealing a NOTCH1 specific signal strength hierarchy for mammalian NOTCH ligands
  • BACE1 can effectively shed the membrane-anchored signaling molecule JAG1 but BACE1 fails to cleave JAG2
  • YAP1 activates JAG2 expression in muscle fibers, which in turn regulates the pool of fetal muscle progenitors via NOTCH1 in a non-cell-autonomous manner
  • cell & other
    REGULATION
    activated by transcriptionally activated by hypoxia in a HIF-1a dependent manner
    ASSOCIATED DISORDERS
    corresponding disease(s) LGMDR27
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in malignant plasma cells from multiple myeloma
    constitutional     --over  
    significantly increased in the colorectal cancer cell lines compared with that of normal colorectal cell line
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • high JAG2 expression may be useful as additional marker to identify aggressive Medulloblastoma (MB)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    therapeutic target for the treatment of colorectal cancer
    ANIMAL & CELL MODELS