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FLASH GENE

Symbol

ILK

contributors: mct/pgu - updated : 07-01-2016

HGNC name	integrin-linked kinase
HGNC id	6040

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       2 novel amino acid residue-altering mutations (2828C>T [Pro943Leu] and 3217C>T [Arg1073X]) in the integrin-interacting domain of the LAMA4 gene and 1 mutation (785C>T [Ala262Val]) in the ILK gene in dilated cardiomyopathy tumoral     --over   in various tumors independent of TGF-beta 1 tumoral     --over   during liver oncogenesis and cirrhosis correlates with activation of Akt but not with other conventional ILK targets tumoral     --over   is associated with tumor progression and a poor (CRC)prognosis in colorectal patients tumoral     --over   promotes cellular transformation, cell survival, epithelial mesenchymal transition (EMT), and metastasis of hormonal cancer cells while inhibition of ILK1 reduces tumor growth and progression

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may represent a novel potential prognostic marker for patients with CRC
Therapy target
	System Type Disorder Pubmed cancer     potential role therapeutic of the anti-mitotic effects of genetic or pharmacological inhibition of ILK cancer     inhibiting ILK offers a selective means of targeting cancer cells cancer reproductive ovary targeting ILK and ITGB4 abrogates the invasive potential of ovarian cancer cancer urinary   could be served as a novel potential therapy target for human bladder cancer

ANIMAL & CELL MODELS