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FLASH GENE

Symbol

ZFPL1

contributors: mct/npt - updated : 30-05-2008

HGNC name	zinc finger protein-like 1
HGNC id	12868

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	4.00 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	see MEN1 MEN1

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 8 - 1400 34.1 310 - Chiu (2008)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Endocrine pancreas       highly   parathyroid         Reproductive male system prostate         male system testis

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two predicted zinc fingers at the N-terminus, the second of which is a likely ring domain
	an atypical class 2 zinc finger domain
	a nuclear localization signal (NLS)
	a C terminal leucine zipper-like motif

conjugated

PhosphoP

HOMOLOGY

Homologene

FAMILY

zinc finger protein family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome
text	localized to the Golgi apparatus, where it exhibited a high degree of overlap with the cis-Golgi matrix protein GOLGA2

basic FUNCTION	ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport
	structural component of the Golgi apparatus
	having an important function in maintaining the integrity of the cis-Golgi and that it does so through interactions with GOLGA2
	can regulate trafficking between the ER and Golgi apparatus

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein

directly interacts with the cis-Golgi matrix protein GOLGA2

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS