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| lack of Pitx3 in mice causes the preferential loss of substantia nigra pars compacta (SNc) mdDA neurons that are most affected in Parkinson disease  | |
Pitx3-deficient mice exhibit severe but selective developmental loss of mDA neurons, with accompanying locomotor deficits resembling those seen in Parkinson's disease (PD) models |
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expression of truncated Pitx3 in the developing lens leads to microphthalmia and aphakia in mice |
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Pitx3(-/-) mice displayed abnormal motor activities, including impaired motor coordination and decreased locomotion |