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FLASH GENE
Symbol CDH8 contributors: shn/npt - updated : 10-08-2009
HGNC name cadherin 8, type 2
HGNC id 1767
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a large N-terminal extracellular domain with 5 subdomains, each containing a cadherin motif
  • a membrane-spanning domain
  • a small highly conserved C-terminal cytoplasmic domain
    • HOMOLOGY
    interspecies ortholog to CDH8, Pan troglodytes
    ortholog to Cdh8, Rattus norvegicus
    ortholog to Cdh8, Musmusculus
    Homologene
    FAMILY
  • cadherin superfamily
    • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    basic FUNCTION
  • may be involved in synaptic adhesion, axon outgrowth and guidance
  • may be implicated in both kidney morphogenesis and tumorigenesis in some types of renal cell carcinoma
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text homophilic cell adhesion activity
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • beta catenin (CTNNB1)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • blockade of the cadherin-8 in cultured rat hippocampal neurons leads to an alterations of dendritic spine morphology
  • Chd8–/– mice died early during embryogenesis, manifesting widespread apoptosis, whereas deletion of p53 ameliorated this developmental arrest