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FLASH GENE

Symbol

CDH8

contributors: shn/npt - updated : 10-08-2009

HGNC name	cadherin 8, type 2
HGNC id	1767

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	382.80 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D16S3132 - D16S3089 - CDH8 - D16S2620 - D16S3129 - qter

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_00196 12 - 2929 NP_001787 130 799 - Kido (1998)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, fetal

Text	expressed at a high level during early embryogenesis

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a large N-terminal extracellular domain with 5 subdomains, each containing a cadherin motif
	a membrane-spanning domain
	a small highly conserved C-terminal cytoplasmic domain

HOMOLOGY

interspecies	ortholog to CDH8, Pan troglodytes
	ortholog to Cdh8, Rattus norvegicus
	ortholog to Cdh8, Musmusculus

Homologene

FAMILY

cadherin superfamily

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION

plasma membrane,junction,tight

basic FUNCTION	may be involved in synaptic adhesion, axon outgrowth and guidance
	may be implicated in both kidney morphogenesis and tumorigenesis in some types of renal cell carcinoma

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	homophilic cell adhesion activity

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

beta catenin (CTNNB1)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	blockade of the cadherin-8 in cultured rat hippocampal neurons leads to an alterations of dendritic spine morphology
	Chd8–/– mice died early during embryogenesis, manifesting widespread apoptosis, whereas deletion of p53 ameliorated this developmental arrest