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FLASH GENE
Symbol CDH8 contributors: shn/npt - updated : 10-08-2009
HGNC name cadherin 8, type 2
HGNC id 1767
Location 16q21      Physical location : 61.687.234 - 62.070.036
Synonym name
  • cadherin-8
  • putative protein product of Nbla04261
    • Synonym symbol(s) Nbla04261
    DNA
    TYPE functioning gene
    STRUCTURE 382.80 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D16S3132 - D16S3089 - CDH8 - D16S2620 - D16S3129 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2929 130 799 - Kido (1998)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text expressed at a high level during early embryogenesis
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a large N-terminal extracellular domain with 5 subdomains, each containing a cadherin motif
  • a membrane-spanning domain
  • a small highly conserved C-terminal cytoplasmic domain
    • HOMOLOGY
    interspecies ortholog to CDH8, Pan troglodytes
    ortholog to Cdh8, Rattus norvegicus
    ortholog to Cdh8, Musmusculus
    Homologene
    FAMILY
  • cadherin superfamily
    • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
    basic FUNCTION
  • may be involved in synaptic adhesion, axon outgrowth and guidance
  • may be implicated in both kidney morphogenesis and tumorigenesis in some types of renal cell carcinoma
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text homophilic cell adhesion activity
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • beta catenin (CTNNB1)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • blockade of the cadherin-8 in cultured rat hippocampal neurons leads to an alterations of dendritic spine morphology
  • Chd8–/– mice died early during embryogenesis, manifesting widespread apoptosis, whereas deletion of p53 ameliorated this developmental arrest