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FLASH GENE
Symbol TAGLN contributors: mct/npt - updated : 24-08-2017
HGNC name transgelin
HGNC id 11553
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nuclear factor binding motifs
  • a calponin-homology (CH) domain
    • conjugated Other
    HOMOLOGY
    interspecies ortholog to murine Tagln
    homolog to C.elegans F43G9.9
    Homologene
    FAMILY
  • family of actin-binding proteins
  • calponin family
    • CATEGORY motor/contractile , regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • acting as a transformation and shape-change sensitive actin cross-linking/gelling protein
  • involved in calcium interactions and contractile properties of the cell contributing to replicative senescence
  • functioning as a suppressor via inhibition of RNF14-enhanced androgen receptor transactivation
  • regulator of MMP9 expression (repressor of 92-kDa type IV collagenase (MMP-9) expression)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text muscle development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • binding to actin
  • binds to actin (multiple regions within the COOH-terminal domain are required for full actin affinity)
  • RNF14-associated negative modulator for AR
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in aortic dissection
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS