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FLASH GENE

Symbol

TAGLN

contributors: mct/npt - updated : 24-08-2017

HGNC name	transgelin
HGNC id	11553

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	Variants 1 and 2 encode the same protein

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 2 5 - 1177 22.6 201 - Yang (2007) variant 1 5 - 1574 22.6 201 - Yang (2007)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous nerve       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly Connective adipose     highly Connective bone     highly Muscular smooth

cells

System Cell Pubmed Species Stage Rna symbol   digestive

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, ageing

Text	senescence fibroblasts, muscle (cardiac, smooth, skeletal)

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	nuclear factor binding motifs
	a calponin-homology (CH) domain

conjugated

Other

HOMOLOGY

interspecies	ortholog to murine Tagln
	homolog to C.elegans F43G9.9

Homologene

FAMILY	family of actin-binding proteins
	calponin family

CATEGORY

motor/contractile , regulatory , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	acting as a transformation and shape-change sensitive actin cross-linking/gelling protein
	involved in calcium interactions and contractile properties of the cell contributing to replicative senescence
	functioning as a suppressor via inhibition of RNF14-enhanced androgen receptor transactivation
	regulator of MMP9 expression (repressor of 92-kDa type IV collagenase (MMP-9) expression)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text	muscle development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein	binding to actin
	binds to actin (multiple regions within the COOH-terminal domain are required for full actin affinity)
	RNF14-associated negative modulator for AR

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in aortic dissection

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS