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FLASH GENE

Symbol

ERBB2

contributors: mct - updated : 05-03-2020

HGNC name	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
HGNC id	3430

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in primary gastric cancer and prostate carcinoma with metastasis and poor prognosis, pancreas, colon and ovary carcinoma, cholangiocarcinoma tumoral       gain of function in primary breast and uterus endometrial cancer and in low grade osteosarcoma with increased survival tumoral somatic mutation       in dilated cardiomyopathy tumoral     --over   in neuro/glioblastoma and in non-small cell lung cancer tumoral   amplification     in many types of cancer, including breast cancer tumoral somatic mutation       in the lung squamous cell carcinoma (kinase domain mutation ) tumoral     --over   in breast cancer cells with poor prognostic (with enhanced tumorigenicity, propensity to metastasize and resistance to endocrine therapy) tumoral   amplification     loss of beclin 1 and ERBB2 amplification (both on 17q21) in breast cancers tumoral     --over   patients breast cancer with higher CCNA2 and ERBB2 expressions had significantly shorter disease-free survival periods tumoral   amplification     may be involved in tumor progression in early gastric cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	overexpression in breast cancer cells are known to be poor prognostic markers and are strong predictors of benefit from treatment with ERBB2-targeting agents
Therapy target
	System Type Disorder Pubmed cancer reproductive breast selected RNA aptamer is a potential cancer imaging agent by targeting malignant cells of breast cancer overexpressing the ERBB2 receptor cancer reproductive breast blockade of ERBB2:TGFB crosstalk may significantly enhance the efficiency of conventional therapies in breast cancer patients with ERBB2 overexpression cancer reproductive breast anti-ERBB2 human compact antibody-RNase (Erb-hcAb-RNase) could be a promising candidate for the immunotherapy of ERBB2-positive tumours cancer reproductive breast therapeutic inhibitors of ERBB3 should be used in combination with HER2 inhibitors and PI3K pathway inhibitors in patients with ERBB2- and PI3K-dependent cancers cancer reproductive breast interactions between ATP2B2 and ERBB2 may represent therapeutic targets for breast cancer cancer reproductive breast strategies to block ERBB2/BECN1 binding and/or increase autophagy may represent a new therapeutic approach for ERBB2-positive breast cancers (PMID: 29610308) cancer reproductive breast interactions between ATP2B2 and ERBB2 may represent therapeutic targets for breast cancer miscelleaneous urinary chronic kidney disease most promising targets for future therapeutic development in Polycystic kidney disease (PKD)are those that target upstream signaling events at cell membranes, such as the vasopressin-2 receptor (AVPR2), EGFR/ERBB2

ANIMAL & CELL MODELS