Citations for
1ERBB2, FUT4, SMYD2
SMYD2 facilitates cancer cell malignancy and xenograft tumor development through ERBB2-mediated FUT4 expression in colon cancer.
Lai Y, Yang Y.
Mol Cell Biochem. Apr 27. doi: 10.1007/s11010-020-03738-2. Online ahead of print 2020
2EGRF, ERBB2, MET, PLXNB1, SEMA3C
SEMA3C drives cancer growth by transactivating multiple receptor tyrosine kinases via Plexin B1.
Peacock JW, Takeuchi A, Hayashi N, Liu L, Tam KJ, Al Nakouzi N, Khazamipour N, Tombe T, Dejima T, Lee KC, Shiota M, Thaper D, Lee WC, Hui DH, Kuruma H, Ivanova L, Yenki P, Jiao IZ, Khosravi S, Mui AL, Fazli L, Zoubeidi A, Daugaard M, Gleave ME, Ong CJ.
EMBO Mol Med 10(2):219-238. doi: 10.15252/emmm.201707689. 2018
3ERBB2
Association of HER2 gene amplification and tumor progression in early gastric cancer.
Kanayama K, Imai H, Usugi E, Shiraishi T, Hirokawa YS, Watanabe M.
Virchows Arch 473(5):559-565. doi: 10.1007/s00428-018-2433-y. Epub 2018 Aug 17. 2018
4BECN1, ERBB2
Increased autophagy blocks HER2-mediated breast tumorigenesis.
Vega-Rubín-de-Celis S, Zou Z, Fernández ÁF, Ci B, Kim M, Xiao G, Xie Y, Levine B.
Proc Natl Acad Sci U S A 115(16):4176-4181. doi: 10.1073/pnas.1717800115. Epub 2018 Apr 2. 2018
5ERBB2, STARD13
In vivo evidence supporting a metastasis suppressor role for Stard13 (Dlc2) in ErbB2 (Neu) oncogene induced mouse mammary tumors.
Basak P, Leslie H, Dillon RL, Muller WJ, Raouf A, Mowat MRA.
Genes Chromosomes Cancer 57(4):182-191. doi: 10.1002/gcc.22519. Epub 2017 Dec 29. 2018
6ERBB2
A novel HER2 gene body enhancer contributes to HER2 expression.
Liu Q, Kulak MV, Borcherding N, Maina PK, Zhang W, Weigel RJ, Qi HH.
Oncogene 37(5):687-694. doi: 10.1038/onc.2017.382. Epub 2017 Oct 16. 2018
7DDX6, ERBB2, FGFR2
DEAD-Box Protein RNA-Helicase DDX6 Regulates the Expression of HER2 and FGFR2 at the Post-Transcriptional Step in Gastric Cancer Cells.
Tajirika T, Tokumaru Y, Taniguchi K, Sugito N, Matsuhashi N, Futamura M, Yanagihara K, Akao Y, Yoshida K.
Int J Mol Sci 19(7). pii: E2005. doi: 10.3390/ijms19072005. 2018
8ERBB2, NUMB, NUMBL, RAB7A
Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation.
Hirai M, Arita Y, McGlade CJ, Lee KF, Chen J, Evans SM.
J Clin Invest 127(2):569-582. doi: 10.1172/JCI91081. Epub 2017 Jan 9. 2017
9ERBB2, SMYD3
Protein lysine methyltransferase SMYD3 is involved in tumorigenesis through regulation of HER2 homodimerization.
Yoshioka Y, Suzuki T, Matsuo Y, Tsurita G, Watanabe T, Dohmae N, Nakamura Y, Hamamoto R.
Cancer Med 6(7):1665-1672. doi: 10.1002/cam4.1099. Epub 2017 Jun 22. 2017
10AKT1, ERBB2
The ectodomain of cadherin-11 binds to erbB2 and stimulates Akt phosphorylation to promote cranial neural crest cell migration.
Mathavan K, Khedgikar V, Bartolo V, Alfandari D.
PLoS One 12(11):e0188963. doi: 10.1371/journal.pone.0188963. eCollection 2017. 2017
11ERBB2
Tumor-linked HER2 expression: association with obesity and lipid-related microenvironment.
Ray A.
Horm Mol Biol Clin Investig 32(3). pii: /j/hmbci.2017.32.issue-3/hmbci-2017-0020/hmbci-2017-0020.xml. doi: 10.1515/hmbci-2017-0020. Review. 2017
12ERBB2, ERBB3
CRISPR-assisted receptor deletion reveals distinct roles for ERBB2 and ERBB3 in skin keratinocytes.
Dahlhoff M, Gaborit N, Bultmann S, Leonhardt H, Yarden Y, Schneider MR.
FEBS J 284(19):3339-3349. doi: 10.1111/febs.14196. Epub 2017 Sep 14. 2017
13ERBB2
Investigation of the role of DNA methylation in the expression of ERBB2 in human myocardium.
Quiñones-Lombraña A, Blair RH, Blanco JG.
Gene 628:286-294. doi: 10.1016/j.gene.2017.07.058. Epub 2017 Jul 21. 2017
14ATP2B2, ERBB2, HSP90AB1
HER2 signaling regulates HER2 localization and membrane retention.
Jeong J, Kim W, Kim LK, VanHouten J, Wysolmerski JJ.
PLoS One 12(4):e0174849. doi: 10.1371/journal.pone.0174849. eCollection 2017. 2017
15ATP2B2, ERBB2, SLC9A3R1
The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2.
Jeong J, VanHouten JN, Kim W, Dann P, Sullivan C, Choi J, Sneddon WB, Friedman PA, Wysolmerski JJ.
J Biol Chem 292(16):6555-6568. doi: 10.1074/jbc.M116.770883. Epub 2017 Feb 24. 2017
16ERBB2, FSIP1
FSIP1 binds HER2 directly to regulate breast cancer growth and invasiveness.
Liu T, Zhang H, Sun L, Zhao D, Liu P, Yan M, Zaidi N, Izadmehr S, Gupta A, Abu-Amer W, Luo M, Yang J, Ou X, Wang Y, Bai X, Wang Y, New MI, Zaidi M, Yuen T, Liu C.
Proc Natl Acad Sci U S A. Jul 18;114(29):7683-7688. doi: 10.1073/pnas.1621486114. Epub 2017 Jul 2017
17ATP2B2, ERBB2
PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer.
Jeong J, VanHouten JN, Dann P, Kim W, Sullivan C, Yu H, Liotta L, Espina V, Stern DF, Friedman PA, Wysolmerski JJ.
Proc Natl Acad Sci U S A 113(3):E282-90. doi: 10.1073/pnas.1516138113. 2016
18EPX, ERBB2
Eosinophil peroxidase activates cells by HER2 receptor engagement and β1-integrin clustering with downstream MAPK cell signaling.
Hennigan K, Conroy PJ, Walsh MT, Amin M, O'Kennedy R, Ramasamy P, Gleich GJ, Siddiqui Z, Glynn S, McCabe O, Mooney C, Harvey BJ, Costello RW, McBryan J.
Clin Immunol 171:1-11. doi: 10.1016/j.clim.2016.08.009. Epub 2016 Aug 9. 2016
19ERBB2, PERP, SPRY2
ErbB2-dependent downregulation of a pro-apoptotic protein Perp is required for oncogenic transformation of breast epithelial cells.
Khan IA, Yoo BH, Masson O, Baron S, Corkery D, Dellaire G, Attardi LD, Rosen KV.
Oncogene 35(44):5759-5769. doi: 10.1038/onc.2016.109. Epub 2016 Apr 25. 2016
20ERBB2, FASN
FASN, ErbB2-mediated glycolysis is required for breast cancer cell migration.
Zhou L, Jiang S, Fu Q, Smith K, Tu K, Li H, Zhao Y.
Oncol Rep 35(5):2715-22. doi: 10.3892/or.2016.4627. Epub 2016 Feb 19. 2016
21ATP2B2, ERBB2
PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer.
Jeong J, VanHouten JN, Dann P, Kim W, Sullivan C, Yu H, Liotta L, Espina V, Stern DF, Friedman PA, Wysolmerski JJ.
Proc Natl Acad Sci U S A 113(3):E282-90. doi: 10.1073/pnas.1516138113. Epub 2016 Jan 4. 2016
22ERBB2, KRT19
Cytokeratin19 induced by HER2/ERK binds and stabilizes HER2 on cell membranes.
Ju JH, Oh S, Lee KM, Yang W, Nam KS, Moon HG, Noh DY, Kim CG, Park G, Park JB, Lee T, Arteaga CL, Shin I.
Cell Death Differ 22(4):665-76. doi: 10.1038/cdd.2014.155. Epub 2014 Oct 24. 2015
23ERBB2, MAP3K11
Human Epidermal Growth Factor Receptor 2 (HER2) Impedes MLK3 Kinase Activity to Support Breast Cancer Cell Survival.
Das S, Sondarva G, Viswakarma N, Nair RS, Osipo C, Tzivion G, Rana B, Rana A.
J Biol Chem 290(35):21705-12. doi: 10.1074/jbc.M115.655563. Epub 2015 Jul 7. 2015
24ERBB2
HER2 missense mutations have distinct effects on oncogenic signaling and migration.
Zabransky DJ, Yankaskas CL, Cochran RL, Wong HY, Croessmann S, Chu D, Kavuri SM, Red Brewer M, Rosen DM, Dalton WB, Cimino-Mathews A, Cravero K, Button B, Kyker-Snowman K, Cidado J, Erlanger B, Parsons HA, Manto KM, Bose R, Lauring J, Arteaga CL, Konstantopoulos K, Park BH.
Proc Natl Acad Sci U S A 112(45):E6205-14. doi: 10.1073/pnas.1516853112. Epub 2015 Oct 27. 2015
25ERBB2, HNRNPH1, SRSF3
SRSF3 and hnRNP H1 regulate a splicing hotspot of HER2 in breast cancer cells.
Gautrey H, Jackson C, Dittrich AL, Browell D, Lennard T, Tyson-Capper A.
RNA Biol 12(10):1139-51. doi: 10.1080/15476286.2015.1076610. Epub 2015 Sep 14. 2015
26ERBB2, ERBIN
Role of Erbin in ErbB2-dependent breast tumor growth.
Tao Y, Shen C, Luo S, Traoré W, Marchetto S, Santoni MJ, Xu L, Wu B, Shi C, Mei J, Bates R, Liu X, Zhao K, Xiong WC, Borg JP, Mei L.
Proc Natl Acad Sci U S A 111(42):E4429-38. doi: 10.1073/pnas.1407139111. 2014
27ERBB2, LINGO1
LINGO-1 regulates oligodendrocyte differentiation by inhibiting ErbB2 translocation and activation in lipid rafts.
Lee X, Shao Z, Sheng G, Pepinsky B, Mi S.
Mol Cell Neurosci 60:36-42. doi: 10.1016/j.mcn.2014.02.006. Epub 2014 Feb 28. 2014
28ERBB2, HOTAIR, MYC, PTEN, RBM38, WIF1
The molecular mechanism of HOTAIR in tumorigenesis, metastasis, and drug resistance.
Zhou X, Chen J, Tang W.
Acta Biochim Biophys Sin (Shanghai) 46(12):1011-5. doi: 10.1093/abbs/gmu104. Epub 2014 Nov 10. Review. 2014
29ERBB2, FASN
Interaction between fatty acid synthase and human epidermal growth receptor 2 (HER2) in osteosarcoma cells.
Long XH, Zhao K, Zhang GM, Zhou Y, Zhou RP, Liu ZL, Zhang ZH.
Int J Clin Exp Pathol 7(12):8777-83. eCollection 2014. 2014
30BDNF, ERBB2, NRG1
RET and NRG1 interplay in Hirschsprung disease.
Gui H, Tang WK, So MT, Proitsi P, Sham PC, Tam PK, Sau-Wai Ngan E, Cherny SS, Garcia-Barceló MM.
Hum Genet 132(5):591-600. doi: 10.1007/s00439-013-1272-9. Epub 2013 Feb 12. 2013
31ERBB2, LOXL2
LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling.
Chang J, Nicolau MM, Cox TR, Wetterskog D, Martens JW, Barker HE, Erler JT.
Breast Cancer Res 15(4):R67. 2013
32ERBB2, ERBIN, NRG1
Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy.
Pan P, Dobrowsky RT.
Acta Neuropathol Commun 1:39. doi: 10.1186/2051-5960-1-39. 2013
33ERBB2, MMP9
MMP-9 increases HER2/neu expression and alters apoptosis levels in human mammary epithelial cells (HMEC).
Fatunmbi M, Shelton J, Aronica SM.
Breast Cancer Res Treat 135(2):519-30. doi: 10.1007/s10549-012-2191-5. Epub 2012 Aug 10. 2012
34ERBB2, ERBB3
Functional isolation of activated and unilaterally phosphorylated heterodimers of ERBB2 and ERBB3 as scaffolds in ligand-dependent signaling.
Zhang Q, Park E, Kani K, Landgraf R.
Proc Natl Acad Sci U S A 109(33):13237-42. doi: 10.1073/pnas.1200105109. Epub 2012 Jun 25. 2012
35ERBB2, ERBIN, NRG1
Erbin is required for myelination in regenerated axons after injury.
Liang C, Tao Y, Shen C, Tan Z, Xiong WC, Mei L.
J Neurosci 32(43):15169-80. doi: 10.1523/JNEUROSCI.2466-12.2012. 2012
36ADAM12, ERBB2
A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion.
Rao VH, Kandel A, Lynch D, Pena Z, Marwaha N, Deng C, Watson P, Hansen LA.
Oncogene 31(23):2888-98. doi: 10.1038/onc.2011.460. Epub 2011 Oct 10. 2012
37ERBB2
In Vitro Selection of RNA Aptamer and Specific Targeting of ErbB2 in Breast Cancer Cells.
Kim MY, Jeong S.
Oligonucleotides ligonucleotides. 2011 Jun 6. [Epub ahead of print] 2011
38ERBB2
The Functional Crosstalk between HER2 Tyrosine Kinase and TGF-β Signaling in Breast Cancer Malignancy.
Wang SE.
J Signal Transduct 2011:804236. Epub 2011 Feb 24. 2011
39ERBB2
When Tumor Suppressor TGFβ Meets the HER2 (ERBB2) Oncogene.
Chow A, Arteaga CL, Wang SE.
J Mammary Gland Biol Neoplasia 16(2):81-8. Epub 2011 Apr 6. 2011
40ERBB2
A novel fully human antitumour immunoRNase targeting ErbB2-positive tumours.
Borriello M, Laccetti P, Terrazzano G, D'Alessio G, De Lorenzo C.
Br J Cancer 104(11):1716-23. Epub 2011 May 10. 2011
41ERBB2
Nuclear ErbB2 Enhances Translation and Cell Growth by Activating Transcription of Ribosomal RNA Genes.
Li LY, Chen H, Hsieh YH, Wang YN, Chu HJ, Chen YH, Chen HY, Chien PJ, Ma HT, Tsai HC, Lai CC, Sher YP, Lien HC, Tsai CH, Hung MC.
Cancer Res ancer Res. 2011 Jun 7. [Epub ahead of print] 2011
42ERBB2
Assessment of ErbB2 (Her2) in oesophageal adenocarcinomas: summary of a revised immunohistochemical evaluation system, bright field double in situ hybridisation and fluorescence in situ hybridisation.
Langer R, Rauser S, Feith M, Nährig JM, Feuchtinger A, Friess H, Höfler H, Walch A.
Mod Pathol od Pathol. 2011 Apr 22. [Epub ahead of print] 2011
43ERBB2, ERBB3
Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase.
Garrett JT, Olivares MG, Rinehart C, Granja-Ingram ND, Sánchez V, Chakrabarty A, Dave B, Cook RS, Pao W, McKinely E, Manning HC, Chang J, Arteaga CL.
Proc Natl Acad Sci U S A 108(12):5021-6. Epub 2011 Mar 8. 2011
44DTNA, ERBB2, ERBB4, NRG1
Neuregulin/ErbB regulate neuromuscular junction development by phosphorylation of α-dystrobrevin.
Schmidt N, Akaaboune M, Gajendran N, Martinez-Pena y Valenzuela I, Wakefield S, Thurnheer R, Brenner HR.
J Cell Biol 195(7):1171-84. doi: 10.1083/jcb.201107083. Epub 2011 Dec 19. 2011
45EGFR, ERBB2, PTPN9
Protein-tyrosine phosphatase PTPN9 negatively regulates ErbB2 and epidermal growth factor receptor signaling in breast cancer cells.
Yuan T, Wang Y, Zhao ZJ, Gu H.
J Biol Chem 285(20):14861-70. Epub 2010 Mar 24.PMID: 20335174 2010
46ERBB2, NRG1
Nrg1/ErbB signaling networks in Schwann cell development and myelination.
Newbern J, Birchmeier C.
Semin Cell Dev Biol emin Cell Dev Biol. 2010 Sep 9. [Epub ahead of print]PMID: 20832498 2010
47ERBB2
ErbB2 requires integrin alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells.
Haenssen KK, Caldwell SA, Shahriari KS, Jackson SR, Whelan KA, Klein-Szanto AJ, Reginato MJ.
J Cell Sci 123(Pt 8):1373-82. Epub 2010 Mar 23.PMID: 20332114 2010
48ERBB2, PIN1
The prolyl isomerase Pin1 enhances HER-2 expression and cellular transformation via its interaction with mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1.
Khanal P, Namgoong GM, Kang BS, Woo ER, Choi HS.
Mol Cancer Ther 9(3):606-16. Epub 2010 Feb 23.PMID: 20179161 2010
49BECN1, ERBB2
Chromosome band 17q21 in breast cancer: significant association between beclin 1 loss and HER2/NEU amplification.
Negri T, Tarantino E, Orsenigo M, Reid JF, Gariboldi M, Zambetti M, Pierotti MA, Pilotti S.
Genes Chromosomes Cancer 49(10):901-9.PMID: 20589936 2010
50ERBB2, MACF1
ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.
Zaoui K, Benseddik K, Daou P, Salaün D, Badache A.
Proc Natl Acad Sci U S A 107(43):18517-22. Epub 2010 Oct 11. 2010
51CCNA2, ERBB2
Prediction of recurrence risk in early breast cancer using human epidermal growth factor 2 and cyclin A2.
Li HP, Ji JF, Hou KY, Lei YT, Zhao HM, Wang J, Zheng J, Liu JY, Wang MP, Xiao Y, Wang YF, Lü YY, Sun Y.
Chin Med J (Engl) 123(4):431-7. Erratum in: Chin Med J (Engl). 2010 Mar;123(5):562. 2010
52ERBB2
ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor.
Alvarado D, Klein DE, Lemmon MA.
Nature 461(7261):287-91. Epub 2009 Aug 30.PMID: 19718021 2009
53CFL1, ERBB2, MEMO1, PLCG1
Memo is a cofilin-interacting protein that influences PLCgamma1 and cofilin activities, and is essential for maintaining directionality during ErbB2-induced tumor-cell migration.
Meira M, Masson R, Stagljar I, Lienhard S, Maurer F, Boulay A, Hynes NE.
J Cell Sci 122(Pt 6):787-97. Epub 2009 Feb 17. 2009
54ERBB2, LDHA
Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth.
Zhao YH, Zhou M, Liu H, Ding Y, Khong HT, Yu D, Fodstad O, Tan M.
Oncogene 28(42):3689-701. doi: 10.1038/onc.2009.229. Epub 2009 Aug 10. 2009
55ERBB2
Direct resequencing of the complete ERBB2 coding sequence reveals an absence of activating mutations in ERBB2 amplified breast cancer.
Zito CI, Riches D, Kolmakova J, Simons J, Egholm M, Stern DF.
Genes Chromosomes Cancer 47(7):633-8. 2008
56APC, ATM, EPHA3, ERBB2, ERBB4, FGFR4
Somatic mutations affect key pathways in lung adenocarcinoma.
Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, Cibulskis K, Sougnez C, Greulich H, Muzny DM, Morgan MB, Fulton L, Fulton RS, Zhang Q, Wendl MC, Lawrence MS, Larson DE, Chen K, Dooling DJ, Sabo A, Hawes AC, Shen H, Jhangiani SN, Lewis LR, Hall O, Zhu Y, Mathew T, Ren Y, Yao J, Scherer SE, Clerc K, Metcalf GA, Ng B, Milosavljevic A, Gonzalez-Garay ML, Osborne JR, Meyer R, Shi X, Tang Y, Koboldt DC, Lin L, Abbott R, Miner TL, Pohl C, Fewell G, Haipek C, Schmidt H, Dunford-Shore BH, Kraja A, Crosby SD, Sawyer CS, Vickery T, Sander S, Robinson J, Winckler W, Baldwin J, Chirieac LR, Dutt A, Fennell T, Hanna M, Johnson BE, Onofrio RC, Thomas RK, Tonon G, Weir BA, Zhao X, Ziaugra L, Zody MC, Giordano T, Orringer MB, Roth JA, Spitz MR, Wistuba II, Ozenberger B, Good PJ, Chang AC, Beer DG, Watson MA, Ladanyi M, Broderick S, Yoshizawa A, Travis WD, Pao W, Province MA, Weinstock GM, Varmus HE, Gabriel SB, Lander ES, Gibbs RA, Meyerson M, Wilson RK.
Nature 455(7216):1069-75. 2008
57ERBB2, ETS1, MMP1
Ets-1 upregulates HER2-induced MMP-1 expression in breast cancer cells.
Park YH, Jung HH, Ahn JS, Im YH.
Biochem Biophys Res Commun 377(2):389-94. Epub 2008 Oct 11. 2008
58ERBB2, RNF11, WWP1
The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11.
Chen C, Zhou Z, Liu R, Li Y, Azmi PB, Seth AK.
Oncogene 27(54):6845-55. Epub 2008 Aug 25. 2008
59EGFR, ERBB2, ERBB3, ERBB4
N-glycan of ErbB family plays a crucial role in dimer formation and tumor promotion.
Takahashi M, Yokoe S, Asahi M, Lee SH, Li W, Osumi D, Miyoshi E, Taniguchi N.
Biochim Biophys Acta 1780(3):520-4. Epub 2007 Nov 6.PMID: 18036567 2008
60ERBB2
Identification of the domain in ErbB2 that restricts ligand-induced degradation.
Shen F, Lin Q, Childress C, Yang W.
Cell Signal 20(4):779-86. Epub 2008 Jan 7.PMID: 18255265 2008
61ERBB2, PTK6
Brk is coamplified with ErbB2 to promote proliferation in breast cancer.
Xiang B, Chatti K, Qiu H, Lakshmi B, Krasnitz A, Hicks J, Yu M, Miller WT, Muthuswamy SK.
Proc Natl Acad Sci U S A 105(34):12463-8. Epub 2008 Aug 21.PMID: 18719096 2008
62DOCK7, ERBB2
ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration.
Yamauchi J, Miyamoto Y, Chan JR, Tanoue A.
J Cell Biol 181(2):351-65. doi: 10.1083/jcb.200709033. 2008
63EGFR, ERBB2, ERBB3, ERBB4
Characterization of a novel tripartite nuclear localization sequence in the EGFR family.
Hsu SC, Hung MC.
J Biol Chem 282(14):10432-40. Epub 2007 Feb 5. 2007
64ERBB2, WWOX
Wwox suppresses prostate cancer cell growth through modulation of ErbB2-mediated androgen receptor signaling.
Qin HR, Iliopoulos D, Nakamura T, Costinean S, Volinia S, Druck T, Sun J, Okumura H, Huebner K.
Mol Cancer Res 5(9):957-65. Epub 2007 Aug 17.PMID: 17704139 2007
65ERBB2
erbB2 is required for G protein-coupled receptor signaling in the heart.
Negro A, Brar BK, Gu Y, Peterson KL, Vale W, Lee KF.
Proc Natl Acad Sci U S A 103(43):15889-93. Epub 2006 Oct 16. 2006
66ERBB2
Altered promoter usage characterizes monoallelic transcription arising with ERBB2 amplification in human breast cancers.
Benz CC, Fedele V, Xu F, Ylstra B, Ginzinger D, Yu M, Moore D, Hall RK, Wolff DJ, Disis ML, Eppenberger-Castori S, Eppenberger U, Schittulli F, Tommasi S, Paradiso A, Scott GK, Albertson DG.
Genes Chromosomes Cancer 45(11):983-94. 2006
67ERBB2
Stable RNA interference of ErbB-2 gene synergistic with epirubicin suppresses breast cancer growth in vitro and in vivo.
Hu X, Su F, Qin L, Jia W, Gong C, Yu F, Guo J, Song E.
Biochem Biophys Res Commun 346(3):778-85. Epub 2006 Jun 9. 2006
68ERBB2
ERBB2 kinase domain mutation in the lung squamous cell carcinoma.
Lee JW, Soung YH, Kim SY, Nam SW, Park WS, Wang YP, Jo KH, Moon SW, Song SY, Lee JY, Yoo NJ, Lee SH.
Cancer Lett 237(1):89-94. Epub 2005 Jul 18. 2006
69ERBB2, ERBB4
Synapses form in skeletal muscles lacking neuregulin receptors.
Escher P, Lacazette E, Courtet M, Blindenbacher A, Landmann L, Bezakova G, Lloyd KC, Mueller U, Brenner HR.
Science 308(5730):1920-3. 2005
70MUC4, ETV4, ERBB2
The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells.
Fauquette V, Perrais M, Cerulis S, Jonckheere N, Ducourouble MP, Aubert JP, Pigny P, Van Seuningen I.
Biochem J 386(Pt 1):35-45. 2005
71ERBB2,LNX1
LNX1 is a perisynaptic Schwann cell specific E3 ubiquitin ligase that interacts with ErbB2.
Young P, Nie J, Wang X, McGlade CJ, Rich MM, Feng G.
Mol Cell Neurosci 30(2):238-48. 2005
72TOP2A, ERBB2
Amplification of the TOP2A gene does not predict high levels of topoisomerase II alpha protein in human breast tumor samples.
Mueller RE, Parkes RK, Andrulis I, O'Malley FP.
Genes Chromosomes Cancer 39(4):288-97. 2004
73TOP2A, ERBB2, TSG17G, THRAP4
Gene copy mapping of the ERBB2/TOP2A region in breast cancer.
Jacobson KK, Morrison LE, Henderson BT, Blondin BA, Wilber KA, Legator MS, O'Hare A, Van Stedum SC, Proffitt JH, Seelig SA, Coon JS.
Genes Chromosomes Cancer 40(1):19-31. 2004
74ERBB2
ErbB2 is required for ductal morphogenesis of the mammary gland.
Jackson-Fisher AJ, Bellinger G, Ramabhadran R, Morris JK, Lee KF, Stern DF.
Proc Natl Acad Sci U S A 101(49):17138-43. Epub 2004 Dec 7. 2004
75ERBB2
Identification and validation of an ERBB2 gene expression signature in breast cancers.
Bertucci F, Borie N, Ginestier C, Groulet A, Charafe-Jauffret E, Adelaide J, Geneix J, Bachelart L, Finetti P, Koki A, Hermitte F, Hassoun J, Debono S, Viens P, Fert V, Jacquemier J, Birnbaum D.
Oncogene 23(14):2564-75. 2004
76ERBB2
Quantitative assessment of HER2/neu expression by real-time PCR and fluorescent in situ hybridization analysis in low-grade osteosarcoma.
Lee WI, Bacchni P, Bertoni F, Maeng YH, Park YK.
Oncol Rep 12(1):125-8. 2004
77ERBB2
Synchronous overexpression of epidermal growth factor receptor and HER2-neu protein is a predictor of poor outcome in patients with stage I non-small cell lung cancer.
Onn A, Correa AM, Gilcrease M, Isobe T, Massarelli E, Bucana CD, O'Reilly MS, Hong WK, Fidler IJ, Putnam JB, Herbst RS.
Clin Cancer Res 10(1 Pt 1):136-43. 2004
78NRG1, NRG2, NRG3, ERBB2, ERBB3, ERBB4, EGFR
Neuregulin promotes autophagic cell death of prostate cancer cells.
Tal-Or P, Di-Segni A, Lupowitz Z, Pinkas-Kramarski R.
Prostate 55(2):147-57. 2003
79ERBB2, GRB7, MIEN1, PGAP3, PNMT, PPP2R1B, STARD3, TCAP
MGC9753 gene, located within PPP1R1B-STARD3-ERBB2-GRB7 amplicon on human chromosome 17q12, encodes the seven-transmembrane receptor with extracellular six-cystein domain.
Katoh M, Katoh M.
Int J Oncol 22(6):1369-74. 2003
80ERBB2
Different mechanisms are implicated in ERBB2 gene overexpression in breast and in other cancers.
Vernimmen D, Gueders M, Pisvin S, Delvenne P, Winkler R.
Br J Cancer 89(5):899-906. 2003
81CASC4, ERBB2
[Evaluation of her-2/neu amplification/overexpression in OSCC with fluorescence in situ hybridization (FISH) and immunohistochemistry]
Scheer M, Prange W, Petmecky K, Schirmacher P, Zoller JE, Kubler AC.
Mund Kiefer Gesichtschir 7(3):138-45. Epub 2003 Mar 7. German. 2003
82ERBB2
ErbB2 is essential in the prevention of dilated cardiomyopathy.
Crone SA, Zhao YY, Fan L, Gu Y, Minamisawa S, Liu Y, Peterson KL, Chen J, Kahn R, Condorelli G, Ross J Jr, Chien KR, Lee KF.
Nat Med 8(5):459-65. 2002
83ERBB2
Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy.
Ozcelik C, Erdmann B, Pilz B, Wettschureck N, Britsch S, Hubner N, Chien KR, Birchmeier C, Garratt AN.
Proc Natl Acad Sci U S A 99(13):8880-5. 2002
84ERBB2
Evaluation of HER-2/neu gene amplification and protein expression in non-small cell lung carcinomas.
Hirsch FR, Varella-Garcia M, Franklin WA, Veve R, Chen L, Helfrich B, Zeng C, Baron A, Bunn PA Jr.
Br J Cancer 86(9):1449-56. 2002
85ERBB2
Herstatin, an autoinhibitor of the human epidermal growth factor receptor 2 tyrosine kinase, modulates epidermal growth factor signaling pathways resulting in growth arrest.
Justman QA, Clinton GM.
J Biol Chem 277(23):20618-24. Epub 2002 Apr 04. 2002
86PTGS2, ERBB2
ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions.
Endo K, Yoon BI, Pairojkul C, Demetris AJ, Sirica AE.
Hepatology 36(2):439-50. 2002
87EGFR, ERBB2
Differential cytoskeletal association of ErbB1 and ErbB2 during keratinocyte differentiation.
Kansra S, Stoll SW, Elder JT.
Biochem Biophys Res Commun 295(5):1108-17. 2002
88ERBB2
Expression of a truncated 100 kDa HER2 splice variant acts as an endogenous inhibitor of tumour cell proliferation.
Aigner A, Juhl H, Malerczyk C, Tkybusch A, Benz CC, Czubayko F.
Oncogene 20(17):2101-11. 2001
89ERBB2
AP-2 transcription factors in the regulation of ERBB2 gene transcription by oestrogen.
Perissi V, Menini N, Cottone E, Capello D, Sacco M, Montaldo F, De Bortoli M.
Oncogene 19(2):280-8. 2000
90EGFR, ERBB2
Gains of the relative genomic content of erbB-1 and erbB-2 in prostate carcinoma and their association with metastasis.
Schwartz S Jr, et al.
Int J Oncol 14(2):367-71. 1999
91ERBB2, KRAS1P
Mutations and amplification of oncogenes in endometrial cancer.
Niederacher D, et al.
Oncology 56(1):59-65. 1999
92ERBB2
The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors.
Klapper LN, et al.
Proc Natl Acad Sci U S A 96(9):4995-5000. 1999
93ERBB2
From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells.
Yeh S, et al.
Proc Natl Acad Sci U S A 96(10):5458-63. 1999
94ERBB2
HER-2/neu (c-erb-B2) gene and protein in breast cancer.
Ross JS, et al.
Am J Clin Pathol 112(1 Suppl 1):S53-67. Review 1999
95ERBB2, ERBB3
The C-terminus of the kinase-defective neuregulin receptor ErbB-3 confers mitogenic superiority and dictates endocytic routing.
Waterman H, et al.
EMBO J 18(12):3348-58 1999
96ERBB2
The HER-2/neu receptor tyrosine kinase gene encodes a secreted autoinhibitor.
Doherty JK, et al.
Proc Natl Acad Sci U S A 96(19):10869-74. 1999
97ERBB2
Rescue of the cardiac defect in ErbB2 mutant mice reveals essential roles of ErbB2 in peripheral nervous system development.
Morris JK, Lin W, Hauser C, Marchuk Y, Getman D, Lee KF.
Neuron 23(2):273-83. 1999
98ERBB2
Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells.
Qiu Y, Ravi L, Kung HJ.
Nature 393(6680):83-5. 1998
99ERBB2
Assignment of v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2) to human chromosome band 17q21.1 by in situ hybridization.
Muleris M, Almeida A, Malfoy B, Dutrillaux B.
Cytogenet Cell Genet 76(1-2):34-5. 1997
100ERBB2, GRB7
Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer.
Kishi T, et al.
Biochem Biophys Res Commun 232 : 5-9. 1997
101ERBB2, TRAF4, STARD3
Two distinct amplified regions at 17q11-q21 involved in human primary breast cancer.
Biche I, et al.
Cancer Res 56 : 3886-3890. 1996
102CTNNB1, ERBB2
c-erbB-2 gene product directly associates with beta-catenin and plakoglobin.
Kanai Y, Ochiai A, Shibata T, Oyama T, Ushijima S, Akimoto S, Hirohashi S.
Biochem Biophys Res Commun 208(3):1067-72. 1995
103ERBB2, ERBB3, ERBB4
ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms.
Tzahar E, Levkowitz G, Karunagaran D, Yi L, Peles E, Lavi S, Chang D, Liu N, Yayon A, Wen D, et al.
J Biol Chem 269(40):25226-33. 1994
104ERBB2
Characterization of a new allele of the human ERBB2 gene by allele-specific competition hybridization.
Ehsani A, et al.
Genomics 15 : 426-429. 1993
105ERBB2
Amplification of the HER-2/neu protooncogene in human endocrine tumors.
Evers BM, et al.
Surgery 112 : 211-218. 1992
106BCR, RAF1, ERBB2, CSF1R
Metaphase and interphase cytogenetics with Alu-PCR-amplified yeast artificial chromosome clones containing the BCR gene and the protooncogenes c-raf-1, c-fms, and c-erbB-2.
Lengauer C, et al.
Cancer Res 52 : 2590-2596. 1992
107ERBB2
Detection and temporal appearance of multiple copies of c-erb-B2 genesin advanced mammary carcinoma using fine needle biopsies and the polymerase chain reaction.
Lšnn U, et al.
Breast Cancer Res Treat 23 : 191-200. 1992
108ERBB2
Specific detection of c-erbB-2 mRNA expression in gastric cancers by the polymerase chain reaction following reverse transcription.
Ninomiya I, et al.
Br J Cancer 66 : 84-87. 1992
109ERBB2
Absence of activating mutations in the transmembrane domain of the c-erbB-2 protooncogene in human lung cancer.
Sachse R, et al.
Jpn J Cancer Res 83 : 1299-1303. 1992
110ERBB2
Alterations of the c-erbB2 gene in human breast cancer.
Zoll B, et al.
J Cancer Res Clin Oncol 118 : 468-473. 1992
111ERBB2
PCR detection of an MboI polymorphism in the ERBB2 (HER2; NEU) gene on chromosome 17q11.2-q12.
Hall JF, et al.
Nucleic Acids Res 19 : 2515. 1991
112ERBB2
G to A polymorphism at amino acid codon 655 of the human erbB-2/HER2 gene.
Papewalis J, et al.
Nucleic Acids Res 19 : 5452. 1991
113ERBB2
Localization of the human erbB-2 gene on normal and rearranged chromosomes 17 to bands q12-21.32.
Popescu NC, et al.
Genomics 4 : 362-366. 1989
114ERBB2
Human breast cancer : correlation of relapse and survival with amplification of the HER-2/neu oncogene.
Slamon DJ, et al.
Science 235 : 177-181. 1987
115ERBB2
A Mr=190,000 glycoprotein phosphorylated on tyrosine residues in epidermal growth factor stimulated KB cells is the product of the C-erbB-2 gene.
Kadowaki T, et al.
Biochem Biophys Res Commun 144 : 699-704. 1987
116ERBB2
erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells.
Di Fiore PP, Pierce JH, Kraus MH, Segatto O, King CR, Aaronson SA.
Science 237(4811):178-82. 1987
117ERBB2
Molecular cloning of the neu gene : absence of gross structural alteration in oncogenic alleles.
Hung MC, et al.
Proc Natl Acad Sci U S A 83 : 261-264. 1986
118GAST, ERBB2, TSHB
Chromosomal assignment of human genes for gastrin, thyrotropin (TSH0)beta subunit and C-erbB-2 by chromosome sorting combined with velocity sedimentation and Southern hybridization.
Fukushige S, et al.
Biochem Biophys Res Commun 134 : 477-483. 1986
119ERBB2
The neu oncogene encodes an epidermal growth factor receptor-related protein.
Bargmann CI, et al.
Nature 319 : 226-230. 1986
120EGFR, ERBB2
Oncogene from rat neuro/glioblastomas (human gene symbol NGL) is located on the proximal long arm of human chromosome 17 and EGFR is confirmed at 7p13-q11.2.
Yang-Feng TL, et al.
(HGM8) Cytogenet Cell Genet 40 : 784. 1985
121ERBB2
Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.
Coussens L, et al.
Science 230 : 1132-1139. 1985