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| TAK1-deficient mous embryonic fibroblasts demonstrated loss of responses to interleukin 1beta and tumor necrosis factor ( | |
antigen-induced immune responses were considerably impaired in mice with B cell-specific TAK1 deficiency ( |
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deletion of TAK1 in mouse T cells prevented the maturation of single-positive thymocytes displaying CD4 or CD8, leading to reduction of T cells in the peripheral tissues ( |
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TAK1 deficiency in keratinocytes led to increased apoptosis in response to anoikis and TNF-& |
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945; treatment and was associated with elevated ROS level ( |
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epithelial-specific TAB1 and TAB2 double- but not TAB1 or TAB2 single-knockout mice phenocopied epithelial-specific TAK1 knockout mice |
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Ablation of both TAB1 and TAB2 diminished the activity of TAK1 in vivo and causes accumulation of ROS in the epithelial tissues |
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homozygous Tak1-deficient mice died early in embryonic development, at day 9.5 |