| 1 | MAP3K7, SWAP70
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| Switch-associated protein 70 protects against nonalcoholic fatty liver disease through suppression of TAK1
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| Qian Q, Li Y, Fu J, Leng D, Dong Z, Shi J, Shi H, Cao D, Cheng X, Hu Y, Luo Q, Hu M, Ran Y, Tang H, Liu H, Liu J.
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| Hepatology. Jun;75(6):1507-1522. doi: 10.1002/hep.32213. Epub 2022 Apr 25. 2022
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| 2 | GRAMD4, ITCH, MAP3K7
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| GRAMD4 inhibits tumour metastasis by recruiting the E3 ligase ITCH to target TAK1 for degradation in hepatocellular carcinoma
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| Ge QY, Chen J, Li GX, Tan XL, Song J, Ning D, Mo J, Du PC, Liu QM, Liang HF, Ding ZY, Zhang XW, Zhang BX.
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| Clin Transl Med. Nov;11(11):e635. doi: 10.1002/ctm2.635 2021
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| 3 | MAP3K7, USP19
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| USP19 Inhibits TNF-α- and IL-1β-Triggered NF-κB Activation by Deubiquitinating TAK1.
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| Lei CQ, Wu X, Zhong X, Jiang L, Zhong B, Shu HB.
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| J Immunol 203(1):259-268. doi: 10.4049/jimmunol.1900083. Epub 2019 May 24.
2019
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| 4 | IKBKB, IRAK4, IRF5, MAP3K7
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| IRAK4 kinase activity controls Toll-like receptor-induced inflammation through the transcription factor IRF5 in primary human monocytes.
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| Cushing L, Winkler A, Jelinsky SA, Lee K, Korver W, Hawtin R, Rao VR, Fleming M, Lin LL.
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| J Biol Chem 292(45):18689-18698. doi: 10.1074/jbc.M117.796912. Epub 2017 Sep 18.
2017
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| 5 | MAP3K7, TRIM8
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| Tripartite Motif 8 Contributes to Pathological Cardiac Hypertrophy Through Enhancing Transforming Growth Factor β-Activated Kinase 1-Dependent Signaling Pathways
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| Chen L, Huang J, Ji YX, Mei F, Wang PX, Deng KQ, Jiang X, Ma G, Li H.
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| Hypertension Feb;69(2):249-258. doi: 10.1161/HYPERTENSIONAHA.116.07741. Epub 2016 Dec 12 2017
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| 6 | MAP3K7, TRIM8
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| The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis
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| Yan FJ, Zhang XJ, Wang WX, Ji YX, Wang PX, Yang Y, Gong J, Shen LJ, Zhu XY, Huang Z, Li H.
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| Hepatology. May;65(5):1492-1511. doi: 10.1002/hep.28971. Epub 2017 Mar 22. 2017
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| 7 | FMTD2, MAP3K7
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| Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia.
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| Wade EM, Daniel PB, Jenkins ZA, McInerney-Leo A, Leo P, Morgan T, Addor MC, Adčs LC, Bertola D, Bohring A, Carter E, Cho TJ, Duba HC, Fletcher E, Kim CA, Krakow D, Morava E, Neuhann T, Superti-Furga A, Veenstra-Knol I, Wieczorek D, Wilson LC, Hennekam RC, Sutherland-Smith AJ, Strom TM, Wilkie AO, Brown MA, Duncan EL, Markie DM, Robertson SP.
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| Am J Hum Genet 99(2):392-406. doi: 10.1016/j.ajhg.2016.05.024. Epub 2016 Jul 15.
2016
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| 8 | CSCF, MAP3K7
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| Heterozygous Mutations in MAP3K7, Encoding TGF-β-Activated Kinase 1, Cause Cardiospondylocarpofacial Syndrome.
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| Le Goff C, Rogers C, Le Goff W, Pinto G, Bonnet D, Chrabieh M, Alibeu O, Nistchke P, Munnich A, Picard C, Cormier-Daire V.
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| Am J Hum Genet 99(2):407-13. doi: 10.1016/j.ajhg.2016.06.005. Epub 2016 Jul 14.
2016
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| 9 | MAP3K7, TNFAIP8L2
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| TIPE2 (Tumor Necrosis Factor α-induced Protein 8-like 2) Is a Novel Negative Regulator of TAK1 Signal.
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| Oho M, Nakano R, Nakayama R, Sakurai W, Miyamoto A, Masuhiro Y, Hanazawa S.
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| J Biol Chem 291(43):22650-22660.
2016
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| 10 | CASP8, MAP3K7, TRADD
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| TAK1 regulates caspase 8 activation and necroptotic signaling via multiple cell death checkpoints.
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| Guo X, Yin H, Chen Y, Li L, Li J, Liu Q.
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| Cell Death Dis 7(9):e2381. doi: 10.1038/cddis.2016.294.
2016
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| 11 | MAP3K7
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| TGFβ activated kinase 1 (TAK1) at the crossroad of B cell receptor and Toll-like receptor 9 signaling pathways in human B cells.
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| Szili D, Bankó Z, Tóth EA, Nagy G, Rojkovich B, Gáti T, Simon M, Hérincs Z, Sármay G.
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| PLoS One 9(5):e96381. doi: 10.1371/journal.pone.0096381. eCollection 2014.
2014
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| 12 | MAP3K7, TAB2
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| TAK1 binding protein 2 is essential for liver protection from stressors.
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| Ikeda Y, Morioka S, Matsumoto K, Ninomiya-Tsuji J.
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| PLoS One 9(2):e88037. doi: 10.1371/journal.pone.0088037. eCollection 2014.
2014
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| 13 | ECSIT, MAP3K7
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| TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-κB.
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| Wi SM, Moon G, Kim J, Kim ST, Shim JH, Chun E, Lee KY.
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| J Biol Chem 289(51):35205-14. doi: 10.1074/jbc.M114.597187. Epub 2014 Nov 4.
2014
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| 14 | MAP3K7
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| The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation.
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| Okada M, Matsuzawa A, Yoshimura A, Ichijo H.
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| J Biol Chem 289(47):32926-36. doi: 10.1074/jbc.M114.579961. Epub 2014 Oct 6.
2014
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| 15 | MAP3K7
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| TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis.
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| Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner DA, Seki E.
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| J Clin Invest 124(8):3566-78. doi: 10.1172/JCI74068. Epub 2014 Jul 1.
2014
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| 16 | IKBKB, MAP3K7, NLK
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| Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKKβ.
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| Li SZ, Zhang HH, Liang JB, Song Y, Jin BX, Xing NN, Fan GC, Du RL, Zhang XD.
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| Biochim Biophys Acta 1843(7):1365-72. doi: 10.1016/j.bbamcr.2014.03.028. Epub 2014 Apr 12.
2014
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| 17 | MAP3K7, RPS6KB1
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| S6K1 negatively regulates TAK1 activity in the toll-like receptor signaling pathway.
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| Kim SY, Baik KH, Baek KH, Chah KH, Kim KA, Moon G, Jung E, Kim ST, Shim JH, Greenblatt MB, Chun E, Lee KY.
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| Mol Cell Biol 34(3):510-21. doi: 10.1128/MCB.01225-13. Epub 2013 Nov 25.
2014
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| 18 | DUSP14, MAP3K7
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| The dual-specificity phosphatase DUSP14 negatively regulates tumor necrosis factor- and interleukin-1-induced nuclear factor-κB activation by dephosphorylating the protein kinase TAK1.
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| Zheng H, Li Q, Chen R, Zhang J, Ran Y, He X, Li S, Shu HB.
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| J Biol Chem 288(2):819-25. doi: 10.1074/jbc.M112.412643. Epub 2012 Dec 10.
2013
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| 19 | MAP3K7, TNFSF11
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| TAK1 is essential for osteoclast differentiation and is an important modulator of cell death by apoptosis and necroptosis.
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| Lamothe B, Lai Y, Xie M, Schneider MD, Darnay BG.
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| Mol Cell Biol 33(3):582-95. doi: 10.1128/MCB.01225-12. Epub 2012 Nov 19.
2013
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| 20 | MAP3K7
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| Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species.
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| Omori E, Inagaki M, Mishina Y, Matsumoto K, Ninomiya-Tsuji J.
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| Proc Natl Acad Sci U S A. 109(9):3365-70 2012
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| 21 | KRAS, MAP3K7
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| TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers.
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| Singh A, Sweeney MF, Yu M, Burger A, Greninger P, Benes C, Haber DA, Settleman J.
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| Cell 148(4):639-50. doi: 10.1016/j.cell.2011.12.033.
2012
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| 22 | MAP3K7
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| Transforming growth factor beta-activated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function.
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| Wang Y, Huang G, Vogel P, Neale G, Reizis B, Chi H.
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| Proc Natl Acad Sci U S A 109(6):E343-52. doi: 10.1073/pnas.1115635109. Epub 2012 Jan 23.
2012
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| 23 | CARD11, FYB1, MAP3K7, SKAP1
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| ADAP regulates cell cycle progression of T cells via control of cyclin E and Cdk2 expression through two distinct CARMA1-dependent signaling pathways.
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| Srivastava R, Burbach BJ, Mitchell JS, Pagán AJ, Shimizu Y.
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| Mol Cell Biol 32(10):1908-17. doi: 10.1128/MCB.06541-11. Epub 2012 Mar 12. 2012
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| 24 | MAP3K7
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| TAK1 regulates SCF expression to modulate PKBα activity that protects keratinocytes from ROS-induced apoptosis.
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| Lam CR, Tan MJ, Tan SH, Tang MB, Cheung PC, Tan NS.
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| Cell Death Differ. 18(7):1120-9. 2011
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| 25 | MAP3K7
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| Phosphorylation and polyubiquitination of transforming growth factor beta-activated kinase 1 are necessary for activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor.
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| Bottero V, Kerur N, Sadagopan S, Patel K, Sharma-Walia N, Chandran B.
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| J Virol. 85(5):1980-93. 2011
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| 26 | MAP3K7
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| The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation.
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| Ahmed N, Zeng M, Sinha I, Polin L, Wei WZ, Rathinam C, Flavell R, Massoumi R, Venuprasad K.
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| Nat Immunol. 12(12):1176-83. 2011
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| 27 | MAP3K7
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| Acute inhibition of TAK1 protects against neuronal death in cerebral ischemia.
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| Neubert M, Ridder DA, Bargiotas P, Akira S, Schwaninger M.
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| Cell Death Differ 18(9):1521-30. doi: 10.1038/cdd.2011.29. Epub 2011 Apr 8.
2011
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| 28 | MAP3K7, USP4
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| USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation.
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| Fan YH, Yu Y, Mao RF, Tan XJ, Xu GF, Zhang H, Lu XB, Fu SB, Yang J.
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| Cell Death Differ 18(10):1547-60. doi: 10.1038/cdd.2011.11. Epub 2011 Feb 18.
2011
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| 29 | MAP3K7, TRIM8
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| Tripartite motif 8 (TRIM8) modulates TNFα- and IL-1β-triggered NF-κB activation by targeting TAK1 for K63-linked polyubiquitination.
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| Li Q, Yan J, Mao AP, Li C, Ran Y, Shu HB, Wang YY.
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| Proc Natl Acad Sci U S A 108(48):19341-6. doi: 10.1073/pnas.1110946108. Epub 2011 Nov 14.
2011
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| 30 | MAP3K7, NLK, TAB2
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| TAB2 scaffolds TAK1 and NLK in repressing canonical Wnt signaling.
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| Li M, Wang H, Huang T, Wang J, Ding Y, Li Z, Zhang J, Li L.
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| J Biol Chem 285(18):13397-404. Epub 2010 Mar 1.
2010
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| 31 | FOXO1, MAP3K7, NLK
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| Regulation of FOXO1 by TAK1-Nemo-like kinase pathway.
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| Kim S, Kim Y, Lee J, Chung J.
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| J Biol Chem 285(11):8122-9. Epub 2010 Jan 8.
2010
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| 32 | ATM, MAP3K7
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| ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress.
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| Wu ZH, Wong ET, Shi Y, Niu J, Chen Z, Miyamoto S, Tergaonkar V.
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| Mol Cell. 40(1):75-86. 2010
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| 33 | MAP3K7, TAB1, TAB2
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| Constitutive association of TGF-beta-activated kinase 1 with the IkappaB kinase complex in the nucleus and cytoplasm of human neutrophils and its impact on downstream processes.
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| Ear T, Fortin CF, Simard FA, McDonald PP.
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| J Immunol 184(7):3897-906. Epub 2010 Mar 3.
2010
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| 34 | FBXW5, MAP3K7
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| An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway.
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| Minoda Y, Sakurai H, Kobayashi T, Yoshimura A, Takaesu G.
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| Biochem Biophys Res Commun 381(3):412-7. Epub 2009 Feb 20.
2009
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| 35 | MAP3K7, TNF
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| TAK1 activation for cytokine synthesis and proliferation of endometriotic cells.
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| Taniguchi F, Harada T, Miyakoda H, Iwabe T, Deura I, Tagashira Y, Miyamoto A, Watanabe A, Suou K, Uegaki T, Terakawa N.
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| Mol Cell Endocrinol 307(1-2):196-204. Epub 2009 May 3.
2009
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| 36 | MAP3K7, MAP3K7IP2, TAB1
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| Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point.
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| Liu Q, Busby JC, Molkentin JD.
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| Nat Cell Biol 11(2):154-61. Epub 2009 Jan 11.PMID: 19136967 2009
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| 37 | MAP3K7, TRAF6, UBE2N, UBE2V1
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| Direct activation of protein kinases by unanchored polyubiquitin chains.
|
| Xia ZP, Sun L, Chen X, Pineda G, Jiang X, Adhikari A, Zeng W, Chen ZJ.
|
| Nature 461(7260):114-9. doi: 10.1038/nature08247. Epub 2009 Aug 12.
2009
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| 38 | MAP3K7
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| TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity.
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| Omori E, Morioka S, Matsumoto K, Ninomiya-Tsuji J.
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| J Biol Chem 283(38):26161-8. Epub 2008 Jul 7.
2008
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| 39 | MAP3K7, TAB1
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| TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappaB.
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| Prickett TD, Ninomiya-Tsuji J, Broglie P, Muratore-Schroeder TL, Shabanowitz J, Hunt DF, Brautigan DL.
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| J Biol Chem 283(28):19245-54. Epub 2008 May 2. 2008
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| 40 | MAP3K7, TAB1
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| TAK1-binding protein 1, TAB1, mediates osmotic stress-induced TAK1 activation but is dispensable for TAK1-mediated cytokine signaling.
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| Inagaki M, Omori E, Kim JY, Komatsu Y, Scott G, Ray MK, Yamada G, Matsumoto K, Mishina Y, Ninomiya-Tsuji J.
|
| J Biol Chem 283(48):33080-6. Epub 2008 Oct 1.
2008
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| 41 | MAP3K7, TAB1
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| Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex.
|
| Mendoza H, Campbell DG, Burness K, Hastie J, Ronkina N, Shim JH, Arthur JS, Davis RJ, Gaestel M, Johnson GL, Ghosh S, Cohen P.
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| Biochem J 409(3):711-22.
2008
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| 42 | VRK2, MAP3K7
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| Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1.
|
| Blanco S, Santos C, Lazo PA.
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| Mol Cell Biol 27(20):7273-83. Epub 2007 Aug 20. 2007
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| 43 | MAP3K7, TAB1
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| TAB1 modulates IL-1alpha mediated cytokine secretion but is dispensable for TAK1 activation.
|
| Bertelsen M, Sanfridson A.
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| Cell Signal 19(3):646-57. Epub 2006 Oct 17. 2007
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| 44 | MAP3K7
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| TAK1 represses transcription of the human telomerase reverse transcriptase gene.
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| Fujiki T, Miura T, Maura M, Shiraishi H, Nishimura S, Imada Y, Uehara N, Tashiro K, Shirahata S, Katakura Y.
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| Oncogene 26(36):5258-66. Epub 2007 Feb 26.
2007
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| 45 | MAP3K7
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| Essential role of TAK1 in thymocyte development and activation.
|
| Liu HH, Xie M, Schneider MD, Chen ZJ.
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| Proc Natl Acad Sci U S A 103(31):11677-82. Epub 2006 Jul 20. 2006
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| 46 | MAP3K7, SOCS3
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| Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex.
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| Frobřse H, Rřnn SG, Heding PE, Mendoza H, Cohen P, Mandrup-Poulsen T, Billestrup N.
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| Mol Endocrinol. 20(7):1587-96. 2006
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| 47 | STAT3, NLK, MAP3K7
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| STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation.
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| Kojima H, Sasaki T, Ishitani T, Iemura S, Zhao H, Kaneko S, Kunimoto H, Natsume T, Matsumoto K, Nakajima K.
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| Proc Natl Acad Sci U S A 102(12):4524-9. Epub 2005 Mar 11. 2005
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| 48 | EDAR, EDARADD, MAP3K7, TAB2, TRAF6
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| TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd.
|
| Morlon A, Munnich A, Smahi A.
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| Hum Mol Genet 14(23):3751-7. Epub 2005 Oct 26. 2005
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| 49 | MAP3K7, MAPK8, XIAP
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| X-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 (JNK1) activation by transforming growth factor beta1 (TGF-beta1) through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 (TAK1).
|
| Kaur S, Wang F, Venkatraman M, Arsura M.
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| J Biol Chem 280(46):38599-608. Epub 2005 Sep 12. 2005
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| 50 | MAP3K7, IL2
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| TAK1-mediated transcriptional activation of CD28-responsive element and AP-1-binding site within the IL-2 promoter in Jurkat T cells.
|
| Sakurai H, Singhirunnusorn P, Shimotabira E, Chino A, Suzuki S, Koizumi K, Saiki I.
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| FEBS Lett 579(29):6641-6. Epub 2005 Nov 9. 2005
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| 51 | MAP3K7, MAP3K3, RIPK1, TNF
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| TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation.
|
| Blonska M, Shambharkar PB, Kobayashi M, Zhang D, Sakurai H, Su B, Lin X.
|
| J Biol Chem 280(52):43056-63. Epub 2005 Oct 31. 2005
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| 52 | MAP3K7
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| Essential function for the kinase TAK1 in innate and adaptive immune responses.
|
| Sato S, Sanjo H, Takeda K, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Matsumoto K, Takeuchi O, Akira S.
|
| Nat Immunol. 6(11):1087-95 2005
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| 53 | MAP3K7
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| PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1.
|
| Shinohara H, Yasuda T, Aiba Y, Sanjo H, Hamadate M, Watarai H, Sakurai H, Kurosaki T.
|
| J Exp Med. 202(10):1423-31. 2005
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| 54 | MAP3K7, JAZF1, SUZ12
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| TIP27: a novel repressor of the nuclear orphan receptor TAK1/TR4.
|
| Nakajima T, Fujino S, Nakanishi G, Kim YS, Jetten AM.
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| Nucleic Acids Res 32(14):4194-204. Print 2004. 2004
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| 55 | MAP3K7, TAB3
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| TAB3, a new binding partner of the protein kinase TAK1.
|
| Cheung PC, Nebreda AR, Cohen P.
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| Biochem J 378(Pt 1):27-34. 2004
|
| 56 | MAP3K7, NLK, WNT1
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| Wnt activates the Tak1/Nemo-like kinase pathway.
|
| Smit L, Baas A, Kuipers J, Korswagen H, van de Wetering M, Clevers H.
|
| J Biol Chem 279(17):17232-40. Epub 2004 Feb 11.
2004
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| 57 | MAP3K7
|
| Sef interacts with TAK1 and mediates JNK activation and apoptosis.
|
| Yang X, Kovalenko D, Nadeau RJ, Harkins LK, Mitchell J, Zubanova O, Chen PY, Friesel R.
|
| J Biol Chem. 279(37):38099-102. 2004
|
| 58 | MAP3K7, PPM1L
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| Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2Cepsilon).
|
| Li MG, Katsura K, Nomiyama H, Komaki K, Ninomiya-Tsuji J, Matsumoto K,Kobayashi T, Tamura S.
|
| J Biol Chem 278(14):12013-21. Epub 2003 Jan 28. 2003
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| 59 | MAP3K7, MAPK14, TAB1
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| TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1.
|
| Ge B, Xiong X, Jing Q, Mosley JL, Filose A, Bian D, Huang S, Han J.
|
| J Biol Chem 278(4):2286-93. Epub 2002 Nov 11. 2003
|
| 60 | MAP3K7
|
| Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR .
|
| Jiang Z, Zamanian-Daryoush M, Nie H, Silva AM, Williams BR, Li X.
|
| J Biol Chem. 278(19):16713-9. 2003
|
| 61 | MAP3K7
|
| Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3.
|
| Edlund S, Bu S, Schuster N, Aspenström P, Heuchel R, Heldin NE, ten Dijke P, Heldin CH, Landström M.
|
| Mol Biol Cell. 14(2):529-44. 2003
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| 62 | IRAK1, MAP3K7
|
| Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol.
|
| Jiang Z, Ninomiya-Tsuji J, Qian Y, Matsumoto K, Li X.
|
| Mol Cell Biol 22(20):7158-67. 2002
|
| 63 | MAP3K7, TNFRSF11A
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| TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB.
|
| Lee SW, Han SI, Kim HH, Lee ZH.
|
| J Biochem Mol Biol 35(4):371-6. 2002
|
| 64 | MAP3K7, TNFRSF11A
|
| Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6.
|
| Mizukami J, Takaesu G, Akatsuka H, Sakurai H, Ninomiya-Tsuji J, Matsumoto K, Sakurai N.
|
| Mol Cell Biol 22(4):992-1000. 2002
|
| 65 | MAP3K7, MAPK8
|
| IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition.
|
| Sanna MG, da Silva Correia J, Ducrey O, Lee J, Nomoto K, Schrantz N, Deveraux QL, Ulevitch RJ.
|
| Mol Cell Biol. 22(6):1754-66. 2002
|
| 66 | IKBKB, MAP3K7
|
| TAK1 is a ubiquitin-dependent kinase of MKK and IKK.
|
| Wang C, Deng L, Hong M, Akkaraju GR, Inoue J, Chen ZJ.
|
| Nature 412(6844):346-51. 2001
|
| 67 | IRAK1, MAP3K7
|
| IRAK and TAK1 are required for IL-18-mediated signaling.
|
| Wald D, Commane M, Stark GR, Li X.
|
| Eur J Immunol 31(12):3747-54. 2001
|
| 68 | MAP3K7
|
| Involvement of Hgs/Hrs in signaling for cytokine-mediated c-fos induction through interaction with TAK1 and Pak1.
|
| Sasaki Y, Sugamura K.
|
| J Biol Chem. 276(32):29943-52. 2001
|
| 69 | MAP3K7
|
| Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation.
|
| Yeung KC, Rose DW, Dhillon AS, Yaros D, Gustafsson M, Chatterjee D, McFerran B, Wyche J, Kolch W, Sedivy JM.
|
| Mol Cell Biol. 21(21):7207-17. 2001
|
| 70 | MAP3K7
|
| Regulation of the TAK1 signaling pathway by protein phosphatase 2C.
|
| Hanada M, Ninomiya-Tsuji J, Komaki K, Ohnishi M, Katsura K, Kanamaru R, Matsumoto K, Tamura S.
|
| J Biol Chem. 276(8):5753-9. 2001
|
| 71 | MAP3K7
|
| TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop.
|
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