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FLASH GENE

Symbol

MAP3K7

contributors: mct/shn - updated : 08-12-2019

HGNC name	mitogen-activated protein kinase kinase kinase 7
HGNC id	6859

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

FMTD2 , CSCF

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     causes dysregulation of reactive oxygen species in keratinocytes, which is causally associated with skin inflammation

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive colon MAP3K7 inhibition is a potential therapeutic strategy for a treatment-refractory subset of colon cancers exhibiting aberrant KRAS and Wnt pathway activation

ANIMAL & CELL MODELS

	TAK1-deficient mous embryonic fibroblasts demonstrated loss of responses to interleukin 1beta and tumor necrosis factor (
	antigen-induced immune responses were considerably impaired in mice with B cell-specific TAK1 deficiency (
	deletion of TAK1 in mouse T cells prevented the maturation of single-positive thymocytes displaying CD4 or CD8, leading to reduction of T cells in the peripheral tissues (
	TAK1 deficiency in keratinocytes led to increased apoptosis in response to anoikis and TNF-&
	945; treatment and was associated with elevated ROS level (
	epithelial-specific TAB1 and TAB2 double- but not TAB1 or TAB2 single-knockout mice phenocopied epithelial-specific TAK1 knockout mice
	Ablation of both TAB1 and TAB2 diminished the activity of TAK1 in vivo and causes accumulation of ROS in the epithelial tissues
	homozygous Tak1-deficient mice died early in embryonic development, at day 9.5