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| Pdk1-null mice died at embryonic day 9.5 with multiple abnormalities, including lack of somites, forebrain, and neural crest-derived tissues |
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mouse strain that showed reduced levels of Pdk1 activity, these hypomorphic Pdk1 mice were viable and fertile, and insulin injection induced the normal phosph |
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orylation responses attributed to Pdk1 activation; nevertheless, these mice were 40 to 50 percent smaller than control animals |
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PDPK1 protein were significantly decreased in the failing hearts of murine models |