| 1 | PDPK1, RPS6KA3
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| PDK1 promotes the inflammatory progress of fibroblast-like synoviocytes by phosphorylating RSK2.
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| Sun C, Sun Y, Jiang D, Bao G, Zhu X, Xu D, Wang Y, Cui Z.
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| Cell Immunol 315:27-33. doi: 10.1016/j.cellimm.2016.10.007. Epub 2016 Nov 1.
2017
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| 2 | PDPK1
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| The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium.
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| Grego-Bessa J, Bloomekatz J, Castel P, Omelchenko T, Baselga J, Anderson KV.
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| Elife 5. pii: e12034. doi: 10.7554/eLife.12034.
2016
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| 3 | PDPK1
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| Phosphoinositide dependent protein kinase 1 is required for exercise-induced cardiac hypertrophy but not the associated mitochondrial adaptations.
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| Noh J, Wende AR, Olsen CD, Kim B, Bevins J, Zhu Y, Zhang QJ, Riehle C, Abel ED.
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| J Mol Cell Cardiol 89(Pt B):297-305. doi: 10.1016/j.yjmcc.2015.10.015. Epub 2015 Oct 22.
2015
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| 4 | PDPK1
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| Phosphoinositide-dependent protein kinase 1 (PDK1) mediates potent inhibitory effects on eosinophils.
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| Sturm EM, Parzmair GP, Radnai B, Frei RB, Sturm GJ, Hammer A, Schuligoi R, Lippe IT, Heinemann A.
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| Eur J Immunol 45(5):1548-59. doi: 10.1002/eji.201445196. Epub 2015 Feb 27.
2015
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| 5 | PDPK1
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| PDK1 regulates B cell differentiation and homeostasis.
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| Baracho GV, Cato MH, Zhu Z, Jaren OR, Hobeika E, Reth M, Rickert RC.
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| Proc Natl Acad Sci U S A 111(26):9573-8. doi: 10.1073/pnas.1314562111. Epub 2014 Jun 16.
2014
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| 6 | AKT1, AKT2, PDPK1
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| PI3 kinase directly phosphorylates Akt1/2 at Ser473/474 in the insulin signal transduction pathway.
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| Tsuchiya A, Kanno T, Nishizaki T.
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| J Endocrinol 220(1):49-59. doi: 10.1530/JOE-13-0172. Print 2014 Jan.
2013
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| 7 | PDPK1, PLCG1
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| A novel regulatory mechanism links PLCγ1 to PDK1.
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| Raimondi C, Chikh A, Wheeler AP, Maffucci T, Falasca M.
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| J Cell Sci 125(Pt 13):3153-63. doi: 10.1242/jcs.100511. Epub 2012 Mar 27.
2012
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| 8 | PDPK1
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| Proliferative and antiapoptotic signaling stimulated by nuclear-localized PDK1 results in oncogenesis.
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| Kikani CK, Verona EV, Ryu J, Shen Y, Ye Q, Zheng L, Qian Z, Sakaue H, Nakamura K, Du J, Ji Q, Ogawa W, Sun LZ, Dong LQ, Liu F.
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| Sci Signal 5(249):ra80. doi: 10.1126/scisignal.2003065.
2012
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| 9 | PDPK1, USP4
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| Ubiquitin-specific protease 4 inhibits mono-ubiquitination of the master growth factor signaling kinase PDK1.
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| Uras IZ, List T, Nijman SM.
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| PLoS One 7(2):e31003. doi: 10.1371/journal.pone.0031003. Epub 2012 Feb 7.
2012
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| 10 | PDPK1
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| PDK1 in apical signaling endosomes participates in the rescue of the polarity complex atypical PKC by intermediate filaments in intestinal epithelia.
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| Mashukova A, Forteza R, Wald FA, Salas PJ.
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| Mol Biol Cell 23(9):1664-74. doi: 10.1091/mbc.E11-12-0988. Epub 2012 Mar 7.
2012
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| 11 | PDPK1
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| Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor.
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| Nagashima K, Shumway SD, Sathyanarayanan S, Chen AH, Dolinski B, Xu Y, Keilhack H, Nguyen T, Wiznerowicz M, Li L, Lutterbach BA, Chi A, Paweletz C, Allison T, Yan Y, Munshi SK, Klippel A, Kraus M, Bobkova EV, Deshmukh S, Xu Z, Mueller U, Szewczak AA, Pan BS, Richon V, Pollock R, Blume-Jensen P, Northrup A, Andersen JN.
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| J Biol Chem 286(8):6433-48. Epub 2010 Nov 30.
2011
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| 12 | PDPK1
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| PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development.
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| Feng Q, Di R, Tao F, Chang Z, Lu S, Fan W, Shan C, Li X, Yang Z.
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| Mol Cell Biol 30(14):3711-21. Epub 2010 May 10. 2010
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| 13 | PDPK1
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| PDK1 coordinates survival pathways and beta-adrenergic response in the heart.
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| Ito K, Akazawa H, Tamagawa M, Furukawa K, Ogawa W, Yasuda N, Kudo Y, Liao CH, Yamamoto R, Sato T, Molkentin JD, Kasuga M, Noda T, Nakaya H, Komuro I.
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| Proc Natl Acad Sci U S A 106(21):8689-94. Epub 2009 May 8.
2009
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| 14 | PDPK1
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| PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles.
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| Reddy P, Adhikari D, Zheng W, Liang S, Hämäläinen T, Tohonen V, Ogawa W, Noda T, Volarevic S, Huhtaniemi I, Liu K.
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| Hum Mol Genet 18(15):2813-24. Epub 2009 May 7.
2009
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| 15 | PDPK1
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| Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding.
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| Yang KJ, Shin S, Piao L, Shin E, Li Y, Park KA, Byun HS, Won M, Hong J, Kweon GR, Hur GM, Seok JH, Chun T, Brazil DP, Hemmings BA, Park J.
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| J Biol Chem 283(3):1480-91. Epub 2007 Nov 16.
2008
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| 16 | CDKN1B, PDPK1
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| PDK1 regulates cell proliferation and cell cycle progression through control of cyclin D1 and p27Kip1 expression.
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| Nakamura K, Sakaue H, Nishizawa A, Matsuki Y, Gomi H, Watanabe E, Hiramatsua R, Tamamori-Adachi M, Kitajima S, Noda T, Ogawa W, Kasuga M.
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| J Biol Chem 283(25):17702-11. Epub 2008 Apr 22. 2008
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| 17 | PDPK1
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| Essential role of PDK1 in regulating endothelial cell migration.
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| Primo L, di Blasio L, Roca C, Droetto S, Piva R, Schaffhausen B, Bussolino F.
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| J Cell Biol 176(7):1035-47. Epub 2007 Mar 19.
2007
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| 18 | PDPK1
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| 3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling.
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| Tanaka H, Fujita N, Tsuruo T.
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| J Biol Chem 280(49):40965-73. Epub 2005 Oct 5. 2005
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| 19 | PDPK1
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| PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation.
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| Lee KY, D'Acquisto F, Hayden MS, Shim JH, Ghosh S.
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| Science 308(5718):114-8. 2005
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| 20 | PDPK1
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| Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure.
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| Mora A, Lipina C, Tronche F, Sutherland C, Alessi DR.
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| Biochem J 385(Pt 3):639-48. 2005
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| 21 | PDPK1, RPS6KA3
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| A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.
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| Frodin M, Jensen CJ, Merienne K, Gammeltoft S.
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| EMBO J 19(12):2924-34. 2000
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| 22 | PDPK1
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| 3-phosphoinositide-dependent protein kinase-1 (PDK1) : structural and functional homology with the Drosophila DSTPK61 kinase.
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| Alessi DR, et al.
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| Curr Biol 7 : 776-789. 1997
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| 23 | PDPK1
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| Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.
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| Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P.
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| Curr Biol 7 : 261-269. 1997
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