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FLASH GENE

Symbol

PDPK1

contributors: mct/npt/pgu - updated : 01-02-2016

HGNC name	3-phosphoinositide dependent protein kinase-1
HGNC id	8816

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   deficiency of the PDK1 pathway in the liver could contribute to development of diabetes, as well as to liver failure

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular aquired heart failure up-regulation of PDPK1 in the heart may emerge as a potential therapeutic strategy for heart failure

ANIMAL & CELL MODELS

	Pdk1-null mice died at embryonic day 9.5 with multiple abnormalities, including lack of somites, forebrain, and neural crest-derived tissues
	mouse strain that showed reduced levels of Pdk1 activity, these hypomorphic Pdk1 mice were viable and fertile, and insulin injection induced the normal phosph
	orylation responses attributed to Pdk1 activation; nevertheless, these mice were 40 to 50 percent smaller than control animals
	PDPK1 protein were significantly decreased in the failing hearts of murine models