| basic FUNCTION
| 3-phosphoinositide (PtdIns(3,4,5)P3, PtdIns(3,4)P2)-dependent kinase 1 |
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playing a central role in cellular signaling by phosphorylating members of the AGC family of kinases, including PKB/Akt  |
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essential for the motility of vascular endothelial cells (ECs) and involved in the regulation of their chemotaxis |
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likely mediating the activation of protein-kinase B AKT/PKB, several PKC isotypes and SGK1, by insulin or growth factors |
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may playing a general role in signaling processes and in development |
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playing a critical role by nucleating the TCR-induced NF-kappaB activation pathway in T cells |
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PDPK1 signaling pathway plays an important role in regulating glucose homoeostasis and controlling expression of insulin-regulated genes |
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play a central regulatory role in many cell signalings between phosphoinositide-3 kinase and various intracellular serine/threonine kinases |
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PDPK1 plays an important role in cell proliferation and cell cycle progression by controlling the expression of both cyclin D1 and CDKN1B |
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plays a critical role in cardiac homeostasis in vivo by serving as a dual effector for cell survival and beta-adrenergic response |
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pivotal effector with dual functions to promote survival of cardiomyocytes and to preserve beta-AR response |
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in oocytes is required to maintain the survival of primordial follicles (PDPK1 signaling in oocytes plays an essential role in preserving the normal reproductive lifespan in females by maintaining the survival of primordial follicles during their long dormancy) |
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essential role in cardiovascular development through activation of AKT1 and SNAI1 |
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in the context of cancer, role in anchorage-independent cell growth, migration, and invasion |
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PDPK1 and PLCG1 are two key enzymes in signal transduction that control several intracellular processes |
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role for nuclear-translocated PDPK1 in oncogenic cellular transformation and tumor progression |
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controls the activation of a subset of AGC kinases |
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is indispensable for B cell survival, proliferation, and growth regulation |
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act as a downstream effector in PI3K signaling and has been implicated in the regulation of neutrophil migration |
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critical role for PDPK1 in transducing inhibitory signals on eosinophil effector function |
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is likely a transducer of PI3K signaling and activates multiple downstream effectors, thereby representing an essential hub coordinating signals coming from extracellular cues to the cytoskeletal machinery, the final executor of cell movement |
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is an important mediator of phosphatidylinositol 3-kinase (PI3K) signaling |
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is required for exercise-induced cardiac hypertrophy but does not contribute to exercise-induced increases in mitochondrial function |
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appropriate levels of membrane-associated PDPK1 are required for stabilization of apical junctions, which promotes cell elongation, during epithelial morphogenesis |
