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FLASH GENE

Symbol

EPX

contributors: mct - updated : 29-11-2017

HGNC name	eosinophil peroxidase
HGNC id	3423

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

EPXD

Susceptibility

to inflammatory bowel disease (IBD)

Variant & Polymorphism other	polymorphisms of EPX are associated to IBD in an age and gender dependent manner, suggesting an essential role of eosinophils in the pathophysiology of IBD

Candidate gene
Marker	EPX-based ELISA is a valid, reliable, repeatable, and specific surrogate marker of eosinophils and/or eosinophil degranulation in the sputum of respiratory patients
Therapy target
	System Type Disorder Pubmed immunology inflammatory   peroxidase inhibitors may have therapeutic potential for the treatment of angiogenesis related diseases driven by inflammation

ANIMAL & CELL MODELS