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FLASH GENE

Symbol

EPX

contributors: mct - updated : 29-11-2017

HGNC name	eosinophil peroxidase
HGNC id	3423

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	EPXD eosinophil peroxidase deficiency
Location	17q22      Physical location : 56.270.088 - 56.282.534
Synonym symbol(s)	EPX-PEN, EPO, EPP, EPXD
EC.number	1.11.1.7

DNA

TYPE	functioning gene
STRUCTURE	12.45 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000502 13 - 2735 NP_000493 - 715 - 2017 27836774

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Connective bone

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic eosinophil Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

tetramer

HOMOLOGY

Homologene

FAMILY

peroxidase family, XPO subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic,granule
text	localized in cytoplasmic granules of eosinophils

basic FUNCTION	having significant inhibitory activity towards Mycobacterium tuberculosis H37Rv
	abundant heme protein in eosinophils that catalyzes the formation of cytotoxic oxidants implicated in asthma, allergic inflammatory disorders, and cancer
	EPX-dependent oxidative damage may play a role in tissue injury in bisulfite-exacerbated eosinophilic inflammatory disorders
	prodction and storage of the two ancestral proteins, RNASE3 and EPX likely share common regulatory mechanisms,
	which result in opposing productions of the two proteins
	preferential role of EPX signaling via a specific surface receptor that leads to neural plasticity
	important and previously unsuspected role for MPO and EPX as drivers of angiogenesis
	MPO and eosinophil peroxidase (EPX) are heme-containing enzymes, well known for their antimicrobial activity, that are released in abundance by innate immune infiltrates at sites of inflammation and injury
	peroxidase enzymes, like MPO and EPX, may play a fundamental role in inhibiting TNFSF11-induced osteoclast differentiation at inflammatory sites of bone fracture and injury
	EPX and MPO are key contributors to cancer progression by augmenting pro-tumorigenic collagen production and angiogenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

tetramer of two light chains and two heavy chains

INTERACTION

DNA

RNA

small molecule	metal binding,
	binds 1 calcium ion per heterodimer

protein

EPX is a novel ligand for the ERBB2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

EPXD

Susceptibility

to inflammatory bowel disease (IBD)

Variant & Polymorphism other	polymorphisms of EPX are associated to IBD in an age and gender dependent manner, suggesting an essential role of eosinophils in the pathophysiology of IBD

Candidate gene
Marker	EPX-based ELISA is a valid, reliable, repeatable, and specific surrogate marker of eosinophils and/or eosinophil degranulation in the sputum of respiratory patients
Therapy target
	System Type Disorder Pubmed immunology inflammatory   peroxidase inhibitors may have therapeutic potential for the treatment of angiogenesis related diseases driven by inflammation

ANIMAL & CELL MODELS