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FLASH GENE

Symbol

TRIP6

contributors: mct - updated : 04-07-2012

HGNC name	thyroid hormone receptor interactor 6
HGNC id	12311

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       moderately Lymphoid/Immune thymus       moderately Nervous nerve cranial nerve     highly Reproductive female system uterus cervix   predominantly   female system ovary     highly Respiratory lung       moderately Skin/Tegument skin       highly Urinary kidney       moderately Visual eye       moderately

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal proline rich region
	three C-terminal cysteine-rich LIM/double zinc finger motifs, through the LIM domain-mediated protein-protein interactions, TRIP6 forms complexes with several molecules involved in actin rearrangement, cell adhesion, and migration
	a nuclear receptor interaction motif (LXXLL)
	C-terminal LIM3 and PDZ-binding domain have been demonstrated to mediate the interaction with the second PDZ domain of PTPL1

HOMOLOGY

intraspecies

homolog to LPP and ZYX (see symbols)

Homologene

FAMILY

LIM containing proteins family, zyxin family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	plasma membrane,junction
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton
	intracellular,nucleus,chromatin/chromosome,telomere
text	TRIP6 and LPP, detected at a small subset of telomeres, perhaps those that are critically short

basic FUNCTION	functioning at a point of convergence between the activated EDG2 and downstream signals involved in cell adhesion and migration
	implicated in cell motility and transcriptional control
	focal adhesion molecule with the capability to shuttle between cell surface and nucleus
	nuclear isoform of TRIP6, acts as a co-activator for AP-1 and NF-kappaB transcription factors
	erves as the molecular mediator of the crosstalk between nuclear receptors and other transcription factors in that it assembles these factors at promoters
	critical downstream regulator of SRC signaling and its phosphorylation is permissive for its presence in the sealing zone where it plays a positive role in osteoclast bone resorptive capacity
	regulates nuclear translocation and the activation of NFKB upon FAS activation or LPA stimulation, and antagonizes FAS-induced apoptosis and further enhances the antiapoptotic effect of LPA in cells that express high levels of TRIP6
	specific LIM proteins (TRIP6 and LPP) are part of complex events occurring in the context of the telomere dysfunction response, and possibly at play during the induction of senescence
	multifunctional protein involved in various physiological and pathological processes, including cell migration and tumorigenesis (POMID: 25673849)

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

PTPN13, PDLIM4 and TRIP6 may function as components of multi-protein complexes at actin-based sub-cellular structures

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein	thyroid hormone receptor
	interacting with endoglin for regulation of the actin cytoskeletal organization
	interacting with the second out of five PDZ motifs in PTP-BL
	interacting with TRIP6 (TRIP6 directly binds to the third PDZ domain of SCRIB via its carboxy-terminus)
	interacted directly with MAGI1 by binding to its fifth PDZ domain
	interaction with NF-kappaB and AP-1 at a glucocorticoid receptor -bound promoter is required for the repression
	binds to the cytoplasmic juxtamembrane domain of FAS and interferes with the recruitment of FADD to FAS
	TRIP6-GRIP1-MYO6 interaction and its regulation on F-actin network play a significant role in dendritic morphogenesis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in glioblastomas

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS