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FLASH GENE

Symbol

MSTN

contributors: mct/pgu - updated : 18-01-2015

HGNC name	myostatin
HGNC id	4223

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	myostatin knockout in mice increases myogenesis and decreases adipogenesis
	Mstn(-/-) mice have a dramatic increase in muscle mass, reduction in fat mass, and resistance to diet-induced and genetic obesity
	Mstn-deficient animals result in an increase of skeletal muscle mass with both hyperplasia and hypertrophy
	Mstn-null mice exhibited delayed skin wound healing attributable to a combination of effects resulting from delayed epidermal reepithelialization and dermal contraction