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FLASH GENE

Symbol

MSTN

contributors: mct/pgu - updated : 18-01-2015

HGNC name	myostatin
HGNC id	4223

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       in gross muscle hypertrophy constitutional       loss of function results in increased muscle mass

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neuromuscular myopathy   myostatin inhibitors have entered clinical trials in patients with muscle wasting and degenerative diseases; inhibitors have the potential of increasing muscle regeneration through the effects of myostatin on myoblasts and also of inhibiting fibrosis th cardiovascular aquired   targeted inhibition of myostatin in cardiac cachexia might be a therapeutic option in the future obesity     . increasing muscle mass by administration of myostatin antagonists may be a promising therapeutic target for treating patients with obesity or diabetes diabete     . increasing muscle mass by administration of myostatin antagonists may be a promising therapeutic target for treating patients with obesity or diabetes diabete     altering the final stages of adipogenesis through targeted GDF8 exposure, may have therapeutic benefit in metabolic disaeses such as diabetes cancer     MSTN inhibition is a potential therapy for muscle wasting diseases, some of which are associated with a depletion of satellite cells

ANIMAL & CELL MODELS

	myostatin knockout in mice increases myogenesis and decreases adipogenesis
	Mstn(-/-) mice have a dramatic increase in muscle mass, reduction in fat mass, and resistance to diet-induced and genetic obesity
	Mstn-deficient animals result in an increase of skeletal muscle mass with both hyperplasia and hypertrophy
	Mstn-null mice exhibited delayed skin wound healing attributable to a combination of effects resulting from delayed epidermal reepithelialization and dermal contraction