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FLASH GENE

Symbol

IRF5

contributors: SGE/npt - updated : 13-07-2018

HGNC name	interferon regulatory factor 5
HGNC id	6120

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Irf5&
	8722;/&
	8722; mice show higher susceptibility to viral infection and decreased serum levels of type I IFN and the inflammatory cytokines IL-6 and TNF-alpha (Lien 2010)
	mice lacking Irf5 accumulate far fewer neutrophils at the site of inflammation due to the reduced levels of chemokines important for neutrophil recruitment, such as the chemokine (C-X-C motif) ligand 1