Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

STAT6

contributors: mct - updated : 26-01-2015

HGNC name	signal transducer and activator of transcription 6, interleukin-4 induced
HGNC id	11368

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       in primary mediastinal B-cell lymphoma tumoral     --over   in the fibromuscular stroma of prostate cancer constitutional       gain of function in renal cysts and is part of a positive feedback loop involving IL13 and its receptor tumoral fusion       NAB2/STAT6, in solitary fibrous tumor (SFT)/hemangiopericytoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed tumor kidney polycystic kidney its pharmacological inhibition is a promising treatment of PKD cancer brain glioma/neuroblstoma new and potentially promising therapeutic target

ANIMAL & CELL MODELS

aberrantly activated in cyst-lining cells in PKD mouse models