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FLASH GENE

Symbol

EEF2

contributors: mct - updated : 26-08-2014

HGNC name	eukaryotic translation elongation factor 2
HGNC id	3214

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	SCA26 spinocerebellar ataxia 26
Location	19p13.3      Physical location : 3.976.054 - 3.985.461
Synonym name	polypeptidyl-tRNA translocase
	elongation factor 2
Synonym symbol(s)	EF2

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	component of a cluster of paralogous genes on chromosomes 19 and 15, including an excised intron coding for the untranslated RNU37
STRUCTURE	9.41 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

Map	see TM6SF2

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001961 15 - 3163 NP_001952 - 858 - 2007 17698016

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine         intestine large intestine colon   highly   mouth tongue     highly Reproductive female system breast mammary gland   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

intraspecies

paralog to TM6SF2

Homologene

FAMILY

GTP-binding elongation factor family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,ribosome
	intracellular,nucleus
text	polyribosome

basic FUNCTION	GTP-dependent translocation of the nascent protein
	is a biochemical sensor that couples miniature synaptic events to local translational suppression in neuronal dendrites
	intracellular target of diphtheria toxin is a modified histidine residue, diphthamide, in the translation elongation factor, EEF2
	EEF2 phosphorylation state localized to the growth cone regulates potentially neurite outgrowth
	EEF2 and RPS6KB1 signaling pathways control protein synthesis and are inhibited during myocardial ischemia

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

EEF2K/EEF2 pathway is a key biochemical sensor that couple neuronal activity to spine plasticity, by controlling the dendritic translation of BDNF

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	GTP

protein	inactivation of EEF2K by CDK1 may serve to keep EEF2 active during mitosis (where calcium levels rise) and thereby permit protein synthesis to proceed in mitotic cells
	TRPM7 via its kinase mediates enhanced Thr56 phosphorylation of EEF2
	EIF5A is closely related to EEF2 function during translation elongation
	PRKAA2 controls cardiac RPS6KB1 under normoxia and regulates EEF2 but not the MTOR-RPS6KB1 pathway during ischemia
	substrate of CSK and could locate in the nucleus
	upon activation, EEF2K phosphorylates and thereby inhibits EEF2, resulting in a dramatic reduction of mRNA translation

cell & other

REGULATION

Phosphorylated by

CSK and CSK-mediated phosphorylation of EEF2 has no effect on its cytoplasmic function in regulating protein translation

ASSOCIATED DISORDERS

corresponding disease(s)

SCA26

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gastric and colorectal cancers

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS