Citations for
1CSK, EEF2
C-terminal Src kinase (Csk)-mediated phosphorylation of eukaryotic elongation factor 2 (eEF2) promotes proteolytic cleavage and nuclear translocation of eEF2.
Yao Q, Liu BQ, Li H, McGarrigle D, Xing BW, Zhou MT, Wang Z, Zhang JJ, Huang XY, Guo L.
J Biol Chem 289(18):12666-78. doi: 10.1074/jbc.M113.546481. Epub 2014 Mar 19. 2014
2EEF2, EEF2K
Elongation factor-2 phosphorylation in dendrites and the regulation of dendritic mRNA translation in neurons.
Heise C, Gardoni F, Culotta L, di Luca M, Verpelli C, Sala C.
Front Cell Neurosci 8:35. doi: 10.3389/fncel.2014.00035. eCollection 2014. Review. 2014
3EEF2, RPS6KB1
Differential regulation of eEF2 and p70S6K by AMPKalpha2 in heart.
Demeulder B, Zarrinpashneh E, Ginion A, Viollet B, Hue L, Rider MH, Vanoverschelde JL, Beauloye C, Horman S, Bertrand L.
Biochim Biophys Acta 1832(6):780-90. doi: 10.1016/j.bbadis.2013.02.015. Epub 2013 Mar 4. 2013
4EEF2
Regulation of neurite outgrowth mediated by localized phosphorylation of protein translational factor eEF2 in growth cones.
Iketani M, Iizuka A, Sengoku K, Kurihara Y, Nakamura F, Sasaki Y, Sato Y, Yamane M, Matsushita M, Nairn AC, Takamatsu K, Goshima Y, Takei K.
Dev Neurobiol 73(3):230-46. doi: 10.1002/dneu.22058. Epub 2012 Nov 26. 2013
5EEF2, PRKAA2, RPS6KB1
Differential regulation of eEF2 and p70S6K by AMPKalpha2 in heart.
Demeulder B, Zarrinpashneh E, Ginion A, Viollet B, Hue L, Rider MH, Vanoverschelde JL, Beauloye C, Horman S, Bertrand L.
Biochim Biophys Acta 1832(6):780-90. doi: 10.1016/j.bbadis.2013.02.015. Epub 2013 Mar 4. 2013
6EEF2, SCA26
A conserved eEF2 coding variant in SCA26 leads to loss of translational fidelity and increased susceptibility to proteostatic insult.
Hekman KE, Yu GY, Brown CD, Zhu H, Du X, Gervin K, Undlien DE, Peterson A, Stevanin G, Clark HB, Pulst SM, Bird TD, White KP, Gomez CM.
Hum Mol Genet 21(26):5472-83. doi: 10.1093/hmg/dds392. Epub 2012 Sep 21. 2012
7EEF2, EEF2K
Coupled activation and degradation of eEF2K regulates protein synthesis in response to genotoxic stress.
Kruiswijk F, Yuniati L, Magliozzi R, Low TY, Lim R, Bolder R, Mohammed S, Proud CG, Heck AJ, Pagano M, Guardavaccaro D.
Sci Signal 5(227):ra40. doi: 10.1126/scisignal.2002718. 2012
8EEF2, EIF5A
eIF5A interacts functionally with eEF2.
Dias CA, Gregio AP, Rossi D, Galvão FC, Watanabe TF, Park MH, Valentini SR, Zanelli CF.
Amino Acids 42(2-3):697-702. doi: 10.1007/s00726-011-0985-0. Epub 2011 Aug 6. 2012
9EEF2
Eukaryotic elongation factor-2 (eEF2): its regulation and peptide chain elongation.
Kaul G, Pattan G, Rafeequi T.
Cell Biochem Funct 29(3):227-34. doi: 10.1002/cbf.1740. Epub 2011 Mar 10. Review. 2011
10EEF2, TRPM7
The channel-kinase TRPM7 regulates phosphorylation of the translational factor eEF2 via eEF2-k.
Perraud AL, Zhao X, Ryazanov AG, Schmitz C.
Cell Signal 23(3):586-93. doi: 10.1016/j.cellsig.2010.11.011. Epub 2010 Nov 25. 2011
11BDNF, EEF2, EEF2K
Synaptic activity controls dendritic spine morphology by modulating eEF2-dependent BDNF synthesis.
Verpelli C, Piccoli G, Zibetti C, Zanchi A, Gardoni F, Huang K, Brambilla D, Di Luca M, Battaglioli E, Sala C.
J Neurosci 30(17):5830-42. doi: 10.1523/JNEUROSCI.0119-10.2010. 2010
12EEF2
Overexpression of eukaryotic elongation factor eEF2 in gastrointestinal cancers and its involvement in G2/M progression in the cell cycle.
Nakamura J, Aoyagi S, Nanchi I, Nakatsuka S, Hirata E, Shibata S, Fukuda M, Yamamoto Y, Fukuda I, Tatsumi N, Ueda T, Fujiki F, Nomura M, Nishida S, Shirakata T, Hosen N, Tsuboi A, Oka Y, Nezu R, Mori M, Doki Y, Aozasa K, Sugiyama H, Oji Y.
Int J Oncol 34(5):1181-9. 2009
13EEF2
Visualization of the eEF2-80S ribosome transition-state complex by cryo-electron microscopy.
Sengupta J, Nilsson J, Gursky R, Kjeldgaard M, Nissen P, Frank J.
J Mol Biol 382(1):179-87. doi: 10.1016/j.jmb.2008.07.004. Epub 2008 Jul 11. 2008
14CDK1, EEF2, EEF2K
cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner.
Smith EM, Proud CG.
EMBO J 27(7):1005-16. doi: 10.1038/emboj.2008.39. Epub 2008 Mar 13. 2008
15DNAJC24, EEF2
Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development.
Webb TR, Cross SH, McKie L, Edgar R, Vizor L, Harrison J, Peters J, Jackson IJ.
J Cell Sci 121(Pt 19):3140-5. doi: 10.1242/jcs.035550. Epub 2008 Sep 2. 2008
16EEF2
Postsynaptic decoding of neural activity: eEF2 as a biochemical sensor coupling miniature synaptic transmission to local protein synthesis.
Sutton MA, Taylor AM, Ito HT, Pham A, Schuman EM.
Neuron 55(4):648-61. 2007
17EEF2
Calcium-induced synergistic inhibition of a translational factor eEF2 in nerve growth cones.
Iizuka A, Sengoku K, Iketani M, Nakamura F, Sato Y, Matsushita M, Nairn AC, Takamatsu K, Goshima Y, Takei K.
Biochem Biophys Res Commun 353(2):244-50. Epub 2006 Dec 13. 2007
18EEF2
Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation.
Spahn CM, Gomez-Lorenzo MG, Grassucci RA, Jørgensen R, Andersen GR, Beckmann R, Penczek PA, Ballesta JP, Frank J.
EMBO J 23(5):1008-19. Epub 2004 Feb 19. 2004
19EEF2
Complete sequence of the coding region of human elongation factor 2 (EF-2) by enzymatic amplification of cDNA from human ovarian granulosa cells.
Rapp G, Klaudiny J, Hagendorff G, Luck MR, Scheit KH.
Biol Chem Hoppe Seyler 370(10):1071-5. 1989
20EEF2
Chromosomal assignment of the gene for human elongation factor 2.
Kaneda Y, et al.
Proc Natl Acad Sci U S A 81 : 3158-3162. 1984