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FLASH GENE
Symbol EEF2 contributors: mct - updated : 26-08-2014
HGNC name eukaryotic translation elongation factor 2
HGNC id 3214
Corresponding disease
SCA26 spinocerebellar ataxia 26
Location 19p13.3      Physical location : 3.976.054 - 3.985.461
Synonym name
  • polypeptidyl-tRNA translocase
  • elongation factor 2
  • Synonym symbol(s) EF2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text component of a cluster of paralogous genes on chromosomes 19 and 15, including an excised intron coding for the untranslated RNU37
    STRUCTURE 9.41 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map see TM6SF2
    Physical map
    LOC284422 19p13.3 similar to HSPC323 MGC4293 19p13.3 hypothetical protein MGC4293 FZR1 19p13.3 hypothetical protein MGC4293 LOC388492 19 LOC388492 MGC20700 19p13.3 hypothetical protein MGC20700 HMG20B 19p13.3 high-mobility group 20B GIPC3 19p13.3 PDZ domain protein GIPC3 LOC388493 19 similar to putative protein (5J182) TBXA2R 19p13.3 thromboxane A2 receptor PIP5K1C 19p13.3 phosphatidylinositol-4-phosphate 5-kinase, type I, gamma TJP3 19p13.3 tight junction protein 3 (zona occludens 3) APBA3 19p13.3 amyloid beta (A4) precursor protein-binding, family A, member 3 (X11-like 2) MRPL54 19p13.3 mitochondrial ribosomal protein L54 MGC15631 19p13.3 hypothetical protein MGC15631 MATK 19p13.3 megakaryocyte-associated tyrosine kinase KIAA1086 19p13.3 megakaryocyte-associated tyrosine kinase LOC388494 19 hypothetical gene supported by AL365406; BC034005 ATCAY 19p13.3 ataxia, cerebellar, Cayman type (caytaxin) ITGB1BP3 19p13.3 integrin beta 1 binding protein 3 DAPK3 19p13.3 death-associated protein kinase 3 EEF2 19p13.3 eukaryotic translation elongation factor 2 PIASY 19p13.3 protein inhibitor of activated STAT protein PIASy LOC387622 19 hypothetical gene supported by NM_020224 FBI1 MAP2K2 7q32 mitogen-activated protein kinase kinase 2 CREB3L3 19p13.3 cAMP responsive element binding protein 3-like 3 SIRT6 19p13.3 sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) KIAA1981 EBI3 19p13.3 Epstein-Barr virus induced gene 3 FLJ10374 19p13.3 hypothetical protein FLJ10374 SHD 19p13.3 src homology 2 domain-containing transforming protein D MGC23244 19p13.3 hypothetical protein MGC23244 FSD1 19p13.3 fibronectin type 3 and SPRY (spla, ryanodine) domain containing (with coiled-coil motif) 1 STAP2 19p13.3 signal-transducing adaptor protein-2 FLJ14981 19p13.3 hypothetical protein FLJ14981 SH3GL1 19p13.3 SH3-domain GRB2-like 1 CHAF1A 19p13.3 chromatin assembly factor 1, subunit A (p150) UBXD1 19p13 UBX domain containing 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 3163 - 858 - 2007 17698016
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     intestinelarge intestinecolon highly
     mouthtongue  highly
    Reproductivefemale systembreastmammary gland highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies paralog to TM6SF2
    Homologene
    FAMILY GTP-binding elongation factor family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus
    text
  • polyribosome
  • basic FUNCTION
  • GTP-dependent translocation of the nascent protein
  • is a biochemical sensor that couples miniature synaptic events to local translational suppression in neuronal dendrites
  • intracellular target of diphtheria toxin is a modified histidine residue, diphthamide, in the translation elongation factor, EEF2
  • EEF2 phosphorylation state localized to the growth cone regulates potentially neurite outgrowth
  • EEF2 and RPS6KB1 signaling pathways control protein synthesis and are inhibited during myocardial ischemia
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • EEF2K/EEF2 pathway is a key biochemical sensor that couple neuronal activity to spine plasticity, by controlling the dendritic translation of BDNF
  • a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP
    protein
  • inactivation of EEF2K by CDK1 may serve to keep EEF2 active during mitosis (where calcium levels rise) and thereby permit protein synthesis to proceed in mitotic cells
  • TRPM7 via its kinase mediates enhanced Thr56 phosphorylation of EEF2
  • EIF5A is closely related to EEF2 function during translation elongation
  • PRKAA2 controls cardiac RPS6KB1 under normoxia and regulates EEF2 but not the MTOR-RPS6KB1 pathway during ischemia
  • substrate of CSK and could locate in the nucleus
  • upon activation, EEF2K phosphorylates and thereby inhibits EEF2, resulting in a dramatic reduction of mRNA translation
  • cell & other
    REGULATION
    Phosphorylated by CSK and CSK-mediated phosphorylation of EEF2 has no effect on its cytoplasmic function in regulating protein translation
    ASSOCIATED DISORDERS
    corresponding disease(s) SCA26
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric and colorectal cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS