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	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

TYROBP

contributors: mct/npt - updated : 03-05-2016

HGNC name	TYRO protein tyrosine kinase binding protein
HGNC id	12449

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

PLOSL1

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function impairs fracture healing constitutional     --over   results in both increased osteoclastogenesis and impaired hematopoiesis underlining the relationship between bone homeostasis and hematopoiesis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   inhibitors of HCST and TYROBP or other proteins involved in this signaling pathway will be attractive therapeutic targets for the treatment of large granular lymphocyte (LGL) leukemia immunology autoimmune   inhibitors of HCST and TYROBP or other proteins involved in this signaling pathway will be attractive therapeutic targets for the treatment of autoimmune diseases and syndromes

ANIMAL & CELL MODELS

Dap12-deficient mice exhibit mild osteopetrosis