| 1 | TYROBP
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| Impaired Fracture Healing Caused by Deficiency of the Immunoreceptor Adaptor Protein DAP12.
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| Kamimura M, Mori Y, Sugahara-Tobinai A, Takai T, Itoi E.
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| PLoS One 10(6):e0128210. doi: 10.1371/journal.pone.0128210. eCollection 2015.
2015
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| 2 | TREM2, TYROBP
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| DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response.
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| Zhong L, Chen XF, Zhang ZL, Wang Z, Shi XZ, Xu K, Zhang YW, Xu H, Bu G.
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| J Biol Chem 290(25):15866-77. doi: 10.1074/jbc.M115.645986. Epub 2015 May 8.
2015
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| 3 | TYROBP
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| DAP12 expression in lung macrophages mediates ischemia/reperfusion injury by promoting neutrophil extravasation.
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| Spahn JH, Li W, Bribriesco AC, Liu J, Shen H, Ibricevic A, Pan JH, Zinselmeyer BH, Brody SL, Goldstein DR, Krupnick AS, Gelman AE, Miller MJ, Kreisel D.
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| J Immunol 194(8):4039-48. doi: 10.4049/jimmunol.1401415. Epub 2015 Mar 11.
2015
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| 4 | SIGLEC15, TYROBP
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| Siglec-15 is a potential therapeutic target for postmenopausal osteoporosis.
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| Kameda Y, Takahata M, Mikuni S, Shimizu T, Hamano H, Angata T, Hatakeyama S, Kinjo M, Iwasaki N.
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| Bone 71:217-26. doi: 10.1016/j.bone.2014.10.027. Epub 2014 Nov 8.
2015
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| 5 | TREM2, TYROBP
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| TREM2 in CNS homeostasis and neurodegenerative disease.
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| Painter MM, Atagi Y, Liu CC, Rademakers R, Xu H, Fryer JD, Bu G.
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| Mol Neurodegener 10:43. doi: 10.1186/s13024-015-0040-9. Review.
2015
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| 6 | KLRC3, KLRD1, TYROBP
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| Human NKG2E is expressed and forms an intracytoplasmic complex with CD94 and DAP12.
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| Orbelyan GA, Tang F, Sally B, Solus J, Meresse B, Ciszewski C, Grenier JC, Barreiro LB, Lanier LL, Jabri B.
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| J Immunol 193(2):610-6. doi: 10.4049/jimmunol.1400556. Epub 2014 Jun 16.
2014
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| 7 | SIGLEC15, TYROBP
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| Mechanism and function of monoclonal antibodies targeting siglec-15 for therapeutic inhibition of osteoclastic bone resorption.
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| Stuible M, Moraitis A, Fortin A, Saragosa S, Kalbakji A, Filion M, Tremblay GB.
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| J Biol Chem 289(10):6498-512. doi: 10.1074/jbc.M113.494542. Epub 2014 Jan 20.
2014
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| 8 | TREM2, TYROBP
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| Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage.
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| Wunderlich P, Glebov K, Kemmerling N, Tien NT, Neumann H, Walter J.
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| J Biol Chem 288(46):33027-36. doi: 10.1074/jbc.M113.517540. Epub 2013 Sep 27.
2013
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| 9 | DOK3, TYROBP
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| A physical interaction between the adaptor proteins DOK3 and DAP12 is required to inhibit lipopolysaccharide signaling in macrophages.
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| Peng Q, Long CL, Malhotra S, Humphrey MB.
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| Sci Signal 6(289):ra72. doi: 10.1126/scisignal.2003801.
2013
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| 10 | TYROBP
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| DAP12 overexpression induces osteopenia and impaired early hematopoiesis.
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| Despars G, Pandruvada SN, Anginot A, Domenget C, Jurdic P, Mazzorana M.
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| PLoS One 8(6):e65297. doi: 10.1371/journal.pone.0065297. Print 2013.
2013
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| 11 | TYROBP
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| DAP12 impacts trafficking and surface stability of killer immunoglobulin-like receptors on natural killer cells.
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| Mulrooney TJ, Posch PE, Hurley CK.
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| J Leukoc Biol 94(2):301-13. doi: 10.1189/jlb.0213093. Epub 2013 May 28.
2013
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| 12 | TREM2, TYROBP
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| Structure, expression pattern and biological activity of molecular complex TREM-2/DAP12.
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| Paradowska-Gorycka A, Jurkowska M.
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| Hum Immunol 74(6):730-7. doi: 10.1016/j.humimm.2013.02.003. Epub 2013 Feb 28. Review.
2013
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| 13 | PLOSL1, TYROBP
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| Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy (PLOSL): a new report of an Italian woman and review of the literature.
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| Bock V, Botturi A, Gaviani P, Lamperti E, Maccagnano C, Piccio L, Silvani A, Salmaggi A.
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| J Neurol Sci 326(1-2):115-9. doi: 10.1016/j.jns.2013.01.021. Epub 2013 Feb 9. Review.
2013
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| 14 | SIGLEC15, TYROBP
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| Siglec-15 regulates osteoclast differentiation by modulating RANKL-induced phosphatidylinositol 3-kinase/Akt and Erk pathways in association with signaling Adaptor DAP12.
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| Kameda Y, Takahata M, Komatsu M, Mikuni S, Hatakeyama S, Shimizu T, Angata T, Kinjo M, Minami A, Iwasaki N.
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| J Bone Miner Res 28(12):2463-75. doi: 10.1002/jbmr.1989.
2013
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| 15 | SIGLEC15, SYK, TNFRSF11A, TNFSF1, TYROBP
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| Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12).
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| Ishida-Kitagawa N, Tanaka K, Bao X, Kimura T, Miura T, Kitaoka Y, Hayashi K, Sato M, Maruoka M, Ogawa T, Miyoshi J, Takeya T.
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| J Biol Chem 287(21):17493-502. doi: 10.1074/jbc.M111.324194. Epub 2012 Mar 26.
2012
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| 16 | FCER1G, FKBP3, OSCAR, TREM2, TYROBP
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| Regulation of ITAM adaptor molecules and their receptors by inhibition of calcineurin-NFAT signalling during late stage osteoclast differentiation.
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| Zawawi MS, Dharmapatni AA, Cantley MD, McHugh KP, Haynes DR, Crotti TN.
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| Biochem Biophys Res Commun 427(2):404-9. doi: 10.1016/j.bbrc.2012.09.077. Epub 2012 Sep 20.
2012
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| 17 | CLEC5A, TYROBP
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| Structural flexibility of the macrophage dengue virus receptor CLEC5A: implications for ligand binding and signaling.
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| Watson AA, Lebedev AA, Hall BA, Fenton-May AE, Vagin AA, Dejnirattisai W, Felce J, Mongkolsapaya J, Palma AS, Liu Y, Feizi T, Screaton GR, Murshudov GN, O'Callaghan CA.
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| J Biol Chem 286(27):24208-18. Epub 2011 May 12.
2011
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| 18 | CLEC5A, TYROBP
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| CLEC5A (MDL-1) is a novel PU.1 transcriptional target during myeloid differentiation.
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| Batliner J, Mancarelli MM, Jenal M, Reddy VA, Fey MF, Torbett BE, Tschan MP.
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| Mol Immunol 48(4):714-9. Epub 2010 Nov 20.
2011
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| 19 | TREM1, TYROBP
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| Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo.
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| Bosco MC, Pierobon D, Blengio F, Raggi F, Vanni C, Gattorno M, Eva A, Novelli F, Cappello P, Giovarelli M, Varesio L.
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| Blood 117(9):2625-39. Epub 2010 Dec 10.
2011
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| 20 | HCST, TREM2, TYROBP
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| TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.
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| Peng Q, Malhotra S, Torchia JA, Kerr WG, Coggeshall KM, Humphrey MB.
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| Sci Signal 3(122):ra38.
2010
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| 21 | CLEC5A, TYROBP
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| Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis.
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| Joyce-Shaikh B, Bigler ME, Chao CC, Murphy EE, Blumenschein WM, Adamopoulos IE, Heyworth PG, Antonenko S, Bowman EP, McClanahan TK, Phillips JH, Cua DJ.
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| J Exp Med 207(3):579-89. Epub 2010 Mar 8.
2010
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| 22 | CLEC5A, HCST, TYROBP
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| Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12.
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| Inui M, Kikuchi Y, Aoki N, Endo S, Maeda T, Sugahara-Tobinai A, Fujimura S, Nakamura A, Kumanogoh A, Colonna M, Takai T.
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| Proc Natl Acad Sci U S A 106(12):4816-21. Epub 2009 Feb 27.
2009
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| 23 | HCST, TYROBP
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| DAP10- and DAP12-associated receptors in innate immunity.
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| Lanier LL.
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| Immunol Rev 227(1):150-60. Review.
2009
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| 24 | HCST, TYROBP
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| A critical role for DAP10 and DAP12 in CD8+ T cell-mediated tissue damage in large granular lymphocyte leukemia.
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| Chen X, Bai F, Sokol L, Zhou J, Ren A, Painter JS, Liu J, Sallman DA, Chen YA, Yoder JA, Djeu JY, Loughran TP, Epling-Burnette PK, Wei S.
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| Blood 113(14):3226-34. Epub 2008 Dec 15.
2009
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| 25 | SYK, TREM2, TYROBP
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| Essential role of DAP12 signaling in macrophage programming into a fusion-competent state.
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| Helming L, Tomasello E, Kyriakides TR, Martinez FO, Takai T, Gordon S, Vivier E.
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| Sci Signal 1(43):ra11.
2008
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| 26 | PLOSL1, TYROBP
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| A novel compound heterozygous mutation in the DAP12 gene in a patient with Nasu-Hakola disease.
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| Kuroda R, Satoh J, Yamamura T, Anezaki T, Terada T, Yamazaki K, Obi T, Mizoguchi K.
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| J Neurol Sci 252(1):88-91. Epub 2006 Nov 27.
2007
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| 27 | TREM2, TYROBP, PLOSL2
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| TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function.
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| Humphrey MB, Daws MR, Spusta SC, Niemi EC, Torchia JA, Lanier LL, Seaman WE, Nakamura MC.
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| J Bone Miner Res 21(2):237-45. Epub 2005 Oct 20. 2006
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| 28 | PLXNA1, TYROBP
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| Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.
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| Takegahara N, Takamatsu H, Toyofuku T, Tsujimura T, Okuno T, Yukawa K, Mizui M, Yamamoto M, Prasad DV, Suzuki K, Ishii M, Terai K, Moriya M, Nakatsuji Y, Sakoda S, Sato S, Akira S, Takeda K, Inui M, Takai T, Ikawa M, Okabe M, Kumanogoh A, Kikutani H.
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| Nat Cell Biol 8(6):615-22. Epub 2006 May 21.
2006
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| 29 | TNFSF11, TYROBP, CSF1, OSCAR
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| Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis.
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| Koga T, Inui M, Inoue K, Kim S, Suematsu A, Kobayashi E, Iwata T, Ohnishi H, Matozaki T, Kodama T, Taniguchi T, Takayanagi H, Takai T.
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| Nature 428(6984):758-63. 2004
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| 30 | KLRK1, KLRC1, KLRC2, KLRC3, KLRC4, TYROBP
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| Human NKG2F is expressed and can associate with DAP12.
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| Kim DK, Kabat J, Borrego F, Sanni TB, You CH, Coligan JE.
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| Mol Immunol 41(1):53-62. 2004
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| 31 | TREM2, TYROBP
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| Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia.
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| Sessa G, Podini P, Mariani M, Meroni A, Spreafico R, Sinigaglia F, Colonna M, Panina P, Meldolesi J.
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| Eur J Neurosci 20(10):2617-28. 2004
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| 32 | CLEC5A, TYROBP, TREM1
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| TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development.
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| Gingras MC, Lapillonne H, Margolin JF.
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| Mol Immunol 38(11):817-24. 2002
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| 33 | TYROBP, TREM2
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| A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells.
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| Bouchon A, Hernandez-Munain C, Cella M, Colonna M.
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| J Exp Med 194(8):1111-22. 2001
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| 34 | PLOSL1, TYROBP
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| Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts.
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| Paloneva J, Kestila M, Wu J, Salminen A, Bohling T, Ruotsalainen V, Hakola P, Bakker AB, Phillips JH, Pekkarinen P, Lanier LL, Timonen T, Peltonen L.
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| Nat Genet 25(3):357-61. 2000
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| 35 | HCST, PLOSL1, TYROBP
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| DAP12 and KAP10 (DAP10)-novel transmembrane adapter proteins of the CD3zeta family.
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| Wilson MJ, Lindquist JA, Trowsdale J.
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| Immunol Res 22(1):21-42. Review. 2000
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| 36 | HCST, TYROBP
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| Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties.
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| Chang C, Dietrich J, Harpur AG, Lindquist JA, Haude A, Loke YW, King A, Colonna M, Trowsdale J, Wilson MJ.
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| J Immunol 163(9):4651-4 1999
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| 37 | TYROBP, LAIR1, LAIR2
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| Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells.
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| Lanier LL, et al.
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| Nature 391 : 703-707. 1998
|