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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CAPN1

contributors: mct/pgu - updated : 06-06-2016

HGNC name	calpain 1, (mu/I) large subunit
HGNC id	1476

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SPG76

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in higher grading of the ovarian carcinoma constitutional     --over   associated with an increase in mitochondrial ROS generation and oxidative damage and a reduction in ATP synthase alpha(ATP5A1) protein and ATP synthase activity

Susceptibility

Variant & Polymorphism

Candidate gene	is a novel molecular candidate to retard age-associated extracellular matrix remodeling and its attendant risk for hypertension and atherosclerosis
Marker
Therapy target
	System Type Disorder Pubmed allergy     potential therapeutic target for the management of allergic inflammation

ANIMAL & CELL MODELS

	Capn1 knock-out mice may serve as a useful model system for neuronal protection and apoptosis in traumatic brain injury and other neurodegenerative disorders in which oxidative stress plays a role
	Calpain-1 protein and activity in mitochondria were elevated in diabetic mouse hearts