| 1 | CAPN1, SPG76
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| Mutations in CAPN1 Cause Autosomal-Recessive Hereditary Spastic Paraplegia.
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| Gan-Or Z, Bouslam N, Birouk N, Lissouba A, Chambers DB, Vérièpe J, Androschuck A, Laurent SB, Rochefort D, Spiegelman D, Dionne-Laporte A, Szuto A, Liao M, Figlewicz DA, Bouhouche A, Benomar A, Yahyaoui M, Ouazzani R, Yoon G, Dupré N, Suchowersky O, Bolduc FV, Parker JA, Dion PA, Drapeau P, Rouleau GA, Bencheikh BO.
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| Am J Hum Genet 98(5):1038-46. doi: 10.1016/j.ajhg.2016.04.002.
2016
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| 2 | CAPN1
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| Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy.
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| Ni R, Zheng D, Xiong S, Hill DJ, Sun T, Gardiner RB, Fan GC, Lu Y, Abel ED, Greer PA, Peng T.
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| Diabetes 65(1):255-68. doi: 10.2337/db15-0963. Epub 2015 Oct 15.
2016
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| 3 | CAPN1, CAPN2, OLR1
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| LOX-1 in macrophage migration in response to ox-LDL and the involvement of calpains.
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| Wang X, Ding Z, Lin J, Guo Z, Mehta JL.
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| Biochem Biophys Res Commun 467(1):135-9. doi: 10.1016/j.bbrc.2015.09.100. Epub 2015 Sep 21.
2015
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| 4 | CAPN1
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| Calpain-1 Mediated Disorder of Pyrophosphate Metabolism Contributes to Vascular Calcification Induced by oxLDL.
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| Tang F, Chan E, Lu M, Zhang X, Dai C, Mei M, Zhang S, Wang H, Song Q.
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| PLoS One 10(6):e0129128. doi: 10.1371/journal.pone.0129128. eCollection 2015.
2015
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| 5 | CAPN1
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| Calpain-1 induces endoplasmic reticulum stress in promoting cardiomyocyte apoptosis following hypoxia/reoxygenation.
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| Zheng D, Wang G, Li S, Fan GC, Peng T.
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| Biochim Biophys Acta 1852(5):882-92. doi: 10.1016/j.bbadis.2015.01.019. Epub 2015 Feb 4.
2015
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| 6 | CAPN1, CAST
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| Altered expression of calcineurin, calpain, calpastatin and HMWCaMBP in cardiac cells following ischemia and reperfusion.
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| Parameswaran S, Sharma RK.
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| Biochem Biophys Res Commun 443(2):604-9. doi: 10.1016/j.bbrc.2013.12.019. Epub 2013 Dec 11.
2014
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| 7 | CAPN1
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| Role of calpain-1 in the early phase of experimental ALS.
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| Stifanese R, Averna M, De Tullio R, Pedrazzi M, Milanese M, Bonifacino T, Bonanno G, Salamino F, Pontremoli S, Melloni E.
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| Arch Biochem Biophys 562:1-8. doi: 10.1016/j.abb.2014.08.006. Epub 2014 Aug 21.
2014
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| 8 | CAPN1
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| Calpain-1 contributes to IgE-mediated mast cell activation.
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| Wu Z, Chen X, Liu F, Chen W, Wu P, Wieschhaus AJ, Chishti AH, Roche PA, Chen WM, Lin TJ.
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| J Immunol 192(11):5130-9. doi: 10.4049/jimmunol.1301677. Epub 2014 Apr 23.
2014
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| 9 | CAPN1
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| Differential functions of calpain 1 during epithelial cell death and adipocyte differentiation in mammary gland involution.
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| Arnandis T, Ferrer-Vicens I, Torres L, García C, Garcia-Trevijano ER, Zaragoza R, Viña JR.
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| Biochem J 459(2):355-68. doi: 10.1042/BJ20130847.
2014
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| 10 | CAPN1, CAST
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| The calpain/calpastatin system has opposing roles in growth and metastatic dissemination of melanoma.
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| Raimbourg Q, Perez J, Vandermeersch S, Prignon A, Hanouna G, Haymann JP, Baud L, Letavernier E.
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| PLoS One 8(4):e60469. doi: 10.1371/journal.pone.0060469. Epub 2013 Apr 2.
2013
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| 11 | CAPN1, CREB1, SLC2A3
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| CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer's disease.
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| Jin N, Qian W, Yin X, Zhang L, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F.
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| Nucleic Acids Res 41(5):3240-56. doi: 10.1093/nar/gks1227. Epub 2013 Jan 22.
2013
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| 12 | ATXN3, CAPN1, CAPN2, CAST
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| Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3).
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| Hübener J, Weber JJ, Richter C, Honold L, Weiss A, Murad F, Breuer P, Wüllner U, Bellstedt P, Paquet-Durand F, Takano J, Saido TC, Riess O, Nguyen HP.
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| Hum Mol Genet 22(3):508-18. doi: 10.1093/hmg/dds449. Epub 2012 Oct 24.
2013
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| 13 | CAPN1, CAPN2, SEMA3A, TRPC5
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| Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse.
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| Kaczmarek JS, Riccio A, Clapham DE.
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| Proc Natl Acad Sci U S A 109(20):7888-92. doi: 10.1073/pnas.1205869109. Epub 2012 Apr 30. 2012
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| 14 | CAPN1
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| Calpain-1 regulation of matrix metalloproteinase 2 activity in vascular smooth muscle cells facilitates age-associated aortic wall calcification and fibrosis.
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| Jiang L, Zhang J, Monticone RE, Telljohann R, Wu J, Wang M, Lakatta EG.
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| Hypertension 60(5):1192-9. doi: 10.1161/HYPERTENSIONAHA.112.196840. Epub 2012 Sep 24.
2012
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| 15 | CAPN1, CAPN2
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| Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation.
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| Santos DM, Xavier JM, Morgado AL, Solá S, Rodrigues CM.
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| PLoS One 7(3):e33468. doi: 10.1371/journal.pone.0033468. Epub 2012 Mar 14.
2012
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| 16 | CAPN1
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| Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress.
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| Yamada KH, Kozlowski DA, Seidl SE, Lance S, Wieschhaus AJ, Sundivakkam P, Tiruppathi C, Chishti I, Herman IM, Kuchay SM, Chishti AH.
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| J Biol Chem 287(16):13182-93. doi: 10.1074/jbc.M111.302612. Epub 2012 Feb 24.
2012
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| 17 | CAPN1, ZFHX3
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| AT motif binding factor 1 (ATBF1) is highly phosphorylated in embryonic brain and protected from cleavage by calpain-1.
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| Zhang S, Kim TS, Dong Y, Kanazawa S, Kawaguchi M, Gao N, Minato H, Takegami T, Nojima T, Asai K, Miura Y.
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| Biochem Biophys Res Commun 427(3):537-41. doi: 10.1016/j.bbrc.2012.09.092. Epub 2012 Sep 26.
2012
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| 18 | CAPN1, RAD21
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| Calpain-1 cleaves Rad21 to promote sister chromatid separation.
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| Panigrahi AK, Zhang N, Mao Q, Pati D.
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| Mol Cell Biol 31(21):4335-47. doi: 10.1128/MCB.06075-11. Epub 2011 Aug 29. 2011
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| 19 | CAPN1, CAPN2, CAST
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| Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in ovarian cancer.
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| Salehin D, Fromberg I, Haugk C, Dohmen B, Georg T, Bohle RM, Bauerschlag D, Thill M, Friedrich M.
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| Eur J Gynaecol Oncol 32(6):628-35.
2011
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| 20 | CAPN1, CAPN2
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| Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival.
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| Takano J, Mihira N, Fujioka R, Hosoki E, Chishti AH, Saido TC.
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| Mol Cell Biol 31(19):4097-106. doi: 10.1128/MCB.05189-11. Epub 2011 Jul 26.
2011
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| 21 | CAPN1, CAPN2, CDKN1B
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| Calpain modulates cyclin-dependent kinase inhibitor 1B (p27(Kip1)) in cells of the osteoblast lineage.
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| Kashiwagi A, Fein MJ, Shimada M.
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| Calcif Tissue Int 89(1):36-42. doi: 10.1007/s00223-011-9491-3. Epub 2011 May 5. 2011
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| 22 | CAPN1, FLG2
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| Deimination of human filaggrin-2 promotes its proteolysis by calpain 1.
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| Hsu CY, Henry J, Raymond AA, Méchin MC, Pendaries V, Nassar D, Hansmann B, Balica S, Burlet-Schiltz O, Schmitt AM, Takahara H, Paul C, Serre G, Simon M.
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| J Biol Chem 286(26):23222-33. doi: 10.1074/jbc.M110.197400. Epub 2011 Apr 29.
2011
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| 23 | CAPN1
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| The role of calpain in diabetes-associated platelet hyperactivation.
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| Randriamboavonjy V, Fleming I.
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| Adv Pharmacol 59:235-57. doi: 10.1016/S1054-3589(10)59008-2. Review.
2010
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| 24 | CAPN1
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| Control of basal autophagy by calpain1 mediated cleavage of ATG5.
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| Xia HG, Zhang L, Chen G, Zhang T, Liu J, Jin M, Ma X, Ma D, Yuan J.
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| Autophagy 6(1):61-6. Epub 2010 Jan 13.
2010
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| 25 | CAPN1, CAST
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| Calpain 1 and Calpastatin expression is developmentally regulated in rat brain.
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| Li Y, Bondada V, Joshi A, Geddes JW.
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| Exp Neurol 220(2):316-9. Epub 2009 Sep 12.
2009
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| 26 | CAPN1, CASP7
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| .Calpain-1 cleaves and activates caspase-7.
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| Gafni J, Cong X, Chen SF, Gibson BW, Ellerby LM.
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| J Biol Chem 284(37):25441-9. doi: 10.1074/jbc.M109.038174. Epub 2009 Jul 18.
2009
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| 27 | CAPN1, CASP7
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| Calpain-1 cleaves and activates caspase-7.
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| Gafni J, Cong X, Chen SF, Gibson BW, Ellerby LM.
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| J Biol Chem 284(37):25441-9. doi: 10.1074/jbc.M109.038174. Epub 2009 Jul 18.
2009
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| 28 | CAPN1
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| N terminus of calpain 1 is a mitochondrial targeting sequence.
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| Badugu R, Garcia M, Bondada V, Joshi A, Geddes JW.
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| J Biol Chem 283(6):3409-17. Epub 2007 Dec 10. 2008
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| 29 | CAPN1,CAPN9
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| The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition.
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| Davis TL, Walker JR, Finerty PJ Jr, Mackenzie F, Newman EM, Dhe-Paganon S.
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| J Mol Biol 366(1):216-29. Epub 2006 Nov 14. 2007
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| 30 | CAPN1, CAPN9
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| The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition.
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| Davis TL, Walker JR, Finerty PJ Jr, Mackenzie F, Newman EM, Dhe-Paganon S.
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| J Mol Biol 366(1):216-29. Epub 2006 Nov 14.
2007
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| 31 | CAPN1
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| Characteristics of mitochondrial calpains.
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| Ozaki T, Tomita H, Tamai M, Ishiguro S.
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| J Biochem 142(3):365-76. Epub 2007 Jul 23.PMID: 17646173 2007
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| 32 | CAPN1, CAPN2
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| Calpain facilitates actin reorganization during glucose-stimulated insulin secretion.
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| Turner MD, Fulcher FK, Jones CV, Smith BT, Aganna E, Partridge CJ, Hitman GA, Clark A, Patel YM.
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| Biochem Biophys Res Commun 352(3):650-5. Epub 2006 Nov 29.
2007
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| 33 | CAPN1
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| Functional dissection of human protease mu-calpain in cell migration using RNAi.
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| Wu M, Yu Z, Fan J, Caron A, Whiteway M, Shen SH.
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| FEBS Lett 580(13):3246-56. Epub 2006 May 6. 2006
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| 34 | HIF1A, CAPN1
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| Calpain mediates a von Hippel-Lindau protein-independent destruction of hypoxia-inducible factor-1alpha.
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| Zhou J, Kšhl R, Herr B, Frank R, BrŸne B.
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| Mol Biol Cell 17(4):1549-58. Epub 2006 Jan 18. 2006
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| 35 | CAPN1, CAPN2, CAST
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| Expression and immunolocalization of the calpain-calpastatin system in the human oocyte.
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| Ben-Aharon I, Ben-Yosef D, Amit A, Shalgi R.
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| Fertil Steril 83(6):1807-13.
2005
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| 36 | CAPN1, CAPN11, CAPN12, CAPN2, CAPN3, CAPN9
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| Both the conserved and the unique gene structure of stomach-specific calpains reveal processes of calpain gene evolution.
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| Hata S, Nishi K, Kawamoto T, Lee HJ, Kawahara H, Maeda T, Shintani Y, Sorimachi H, Suzuki K.
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| J Mol Evol 53(3):191-203.
2001
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| 37 | CAPN1, MEN1, MAP4K2, VEGFB, NRXN2
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| A 500-kb sequence-ready cosmid contig and transcript map of the MEN1 region on 11q13.
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| Bergman L, Silins G, Grimmond S, Hummerich H, Stewart C, Little P, Hayward N.
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| Genomics 55(1):49-56. 1999
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| 38 | CAPN1, FAU, KAT5, MAP3K11, MEN1, PABYL, PLCB3, PYGM, RELA, SEA, SF1, SIPA1
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| A transcript map encompassing the multiple endocrine neoplasia type-1 (MEN1) locus on chromosome 11q13.
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| Sawicki M, Arnold E, Ebrahimi S, Duell T, Jin S, Wood T, Chakrabarti R, Peters J, Wan Y, Samara G, Weier HU, Udar N, Passaro E Jr, Srivatsan ES.
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| Genomics 42(3):405-12. 1997
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| 39 | MEN1, CAPN1
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| Genetic mapping studies of 40 loci and 23 cosmids in chromosome 11p13-11q13, and exclusion of mu-calpain as the multiple endocrine neoplasia type 1 gene.
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| Pang JT, et al.
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| Hum Genet 97 : 732-741. 1996
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| 40 | CAPN1, CAPN2, CAPN3, CAPNS1
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| Four genes for the calpain family locate on four distinct human chromosomes.
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| Ohno S, et al.
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| Cytogenet Cell Genet 53 : 225-229. 1990
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