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FLASH GENE

Symbol

MT1E

contributors: mct/npt - updated : 13-03-2009

HGNC name	metallothionein 1E
HGNC id	7397

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	1.44 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed MT1E 3 - 519 5.88 61 - West (1990)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Endocrine neuroendocrine pituitary     highly Reproductive female system ovary     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

MetalloP

HOMOLOGY

Homologene

FAMILY	metallothionein superfamily
	type 1 family

CATEGORY

motor/contractile , storage

SUBCELLULAR LOCALIZATION

basic FUNCTION	involved in multiple protective pathways including binding of toxic metals, free radical scavenging, and oxidative stress (Oppermann 2001)
	having a necessary role for cancer cell migration (Wu 2008)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	heavy metal ions

protein

cell & other

REGULATION

induced by

heavy metal ions

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in bladder cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS