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FLASH GENE

Symbol

MT1A

contributors: mct/npt - updated : 22-10-2017

HGNC name	metallothionein 1A
HGNC id	7393

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function up-regulated in adult dorsal root ganglion (DRG) after a conditioning lesion of the CNS constitutional     --low   significant decreases in placental MT1A and SLC30A1 mRNA expressions to the levels below the threshold values may be a crucial factor to determine the presence of fetal heart malformations, by zinc deficiency constitutional       loss of function significantly down-regulated in proliferating keloid fibroblast (KF) constitutional     --over   MT1A/MT2A expression was increased in hippocampi from temporal lobe epilepsy (TLE) patients

Susceptibility

to type 2 diabetes

Variant & Polymorphism SNP	rs8052394 SNP is most likely the predisposition gene locus for diabetes (Yang 2008)

Candidate gene	its mRNA expression in peripheral blood lymphocytes may be used as a biomarker for renal dysfunction in occupational cadmium exposure (Chang 2009)
Marker
Therapy target

ANIMAL & CELL MODELS