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Symbol MT1A contributors: mct/npt - updated : 22-10-2017
HGNC name metallothionein 1A
HGNC id 7393
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       gain of function
up-regulated in adult dorsal root ganglion (DRG) after a conditioning lesion of the CNS
constitutional     --low  
significant decreases in placental MT1A and SLC30A1 mRNA expressions to the levels below the threshold values may be a crucial factor to determine the presence of fetal heart malformations, by zinc deficiency
constitutional       loss of function
significantly down-regulated in proliferating keloid fibroblast (KF)
constitutional     --over  
MT1A/MT2A expression was increased in hippocampi from temporal lobe epilepsy (TLE) patients
  • to type 2 diabetes
  • Variant & Polymorphism SNP rs8052394 SNP is most likely the predisposition gene locus for diabetes (Yang 2008)
    Candidate gene
  • its mRNA expression in peripheral blood lymphocytes may be used as a biomarker for renal dysfunction in occupational cadmium exposure (Chang 2009)
  • Marker
    Therapy target