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FLASH GENE
Symbol MT1A contributors: mct/npt - updated : 22-10-2017
HGNC name metallothionein 1A
HGNC id 7393
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two metal-binding domains
    • conjugated MetalloP , Other
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • metallothionein superfamily
  • type 1 family
    • CATEGORY regulatory , storage
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • playing roles in hepatic metabolism,regulation and storage of trace-metals
  • playing a role in zinc and copper homeostasis during development
  • regulating synthesis, assembly or activity of zinc metalloproteins
  • protecting against copper toxicity
  • downstream target of VEZF1 in endothelial cells and is involved in the regulation of angiogenesis (Miyashita 2005)
  • cysteine-rich, metal-binding protein providing protection against cadmium toxicity in mammals (Rigby Duncan 2008)
  • have crucial biological functions including cell proliferation and apoptosis, homeostasis of essential metals, cellular free radical scavenging, and metal detoxification (Kayaalti 2009)
  • metal-binding protein, reported to promote cell proliferation
  • is epigenetically regulated by SPI1 during monocytic differentiation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • heavy metal ion transport
  • zinc and copper homeostasis
    • PATHWAY
    metabolism
    signaling
    a component
  • TTR-MT1A/MT2A protein complex (Goncalves 2008)
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • heavy metal ions
  • Zn2+
  • copper Cu2+
  • cadmium Cd2+
    • protein
  • MT1A is a direct target gene negatively regulated by SPI1
  • YWHAE-induced expression of ZNF479, a novel potential transcriptional regulator by gene expression profiling and ZNF479 contributed to YWHAE-suppressed MT1A expression
    • cell & other
    REGULATION
    induced by heavy metal ions
    glucocorticoids
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    up-regulated in adult dorsal root ganglion (DRG) after a conditioning lesion of the CNS
    constitutional     --low  
    significant decreases in placental MT1A and SLC30A1 mRNA expressions to the levels below the threshold values may be a crucial factor to determine the presence of fetal heart malformations, by zinc deficiency
    constitutional       loss of function
    significantly down-regulated in proliferating keloid fibroblast (KF)
    constitutional     --over  
    MT1A/MT2A expression was increased in hippocampi from temporal lobe epilepsy (TLE) patients
    Susceptibility
  • to type 2 diabetes
    • Variant & Polymorphism SNP rs8052394 SNP is most likely the predisposition gene locus for diabetes (Yang 2008)
    Candidate gene
  • its mRNA expression in peripheral blood lymphocytes may be used as a biomarker for renal dysfunction in occupational cadmium exposure (Chang 2009)
    • Marker
    Therapy target
    ANIMAL & CELL MODELS