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FLASH GENE

Symbol

ADRA1A

contributors: mct/ - updated : 13-06-2015

HGNC name	adrenergic, alpha-1A-, receptor
HGNC id	277

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	seven transmembrane segments (7TM)
	carboxyl-terminal Ser or Thr residues may be phosphorylated
	three N-linked glycosylation sites in its N terminus

conjugated

GlycoP , LipoP , PhosphoP

HOMOLOGY

interspecies	ortholog to rattus Adra1a
	ortholog to murine Adra1a

Homologene

FAMILY	G protein coupled receptor superfamily
	G-protein coupled receptor 1 family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
text	integral to plasma membrane

basic FUNCTION	mediating G(1)-S cell-cycle arrest
	mediating its action by association with G proteins that
	activate a phosphatidylinositol-Ca2+ second messenger system
	mediation of its effect by G(q) and G(11) proteins

CELLULAR PROCESS	cell life, proliferation/growth
	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

text	negative regulation of cell proliferation; smooth muscle contraction

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

APLNR-enhanced response requires ADRA1A to contract vessels coordinately

cell & other

REGULATION

Other

regulated by complex splicing mechanisms

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS