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FLASH GENE

Symbol

ADRA1A

contributors: mct/ - updated : 13-06-2015

HGNC name	adrenergic, alpha-1A-, receptor
HGNC id	277

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Digestive liver       highly Reproductive male system prostate       Homo sapiens   male system male genital tract epididymis     Homo sapiens   male system seminal vesicles       Homo sapiens   male system testis       Homo sapiens Respiratory respiratory tract larynx     predominantly Urinary ureter         Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	seven transmembrane segments (7TM)
	carboxyl-terminal Ser or Thr residues may be phosphorylated
	three N-linked glycosylation sites in its N terminus

conjugated

GlycoP , LipoP , PhosphoP

HOMOLOGY

interspecies	ortholog to rattus Adra1a
	ortholog to murine Adra1a

Homologene

FAMILY	G protein coupled receptor superfamily
	G-protein coupled receptor 1 family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
text	integral to plasma membrane

basic FUNCTION	mediating G(1)-S cell-cycle arrest
	mediating its action by association with G proteins that
	activate a phosphatidylinositol-Ca2+ second messenger system
	mediation of its effect by G(q) and G(11) proteins

CELLULAR PROCESS	cell life, proliferation/growth
	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

text	negative regulation of cell proliferation; smooth muscle contraction

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

APLNR-enhanced response requires ADRA1A to contract vessels coordinately

cell & other

REGULATION

Other

regulated by complex splicing mechanisms

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS