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FLASH GENE

Symbol

ATP1B3

contributors: - updated : 03-07-2007

HGNC name	ATPase, Na+/K+ transporting, beta 3 polypeptide
HGNC id	806

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed - - - 1600 - 279 widely Malik - - - 1800 - 279 widely Malik

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive mouth       highly   pharynx       highly   stomach       highly Reproductive male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

dimer

HOMOLOGY

intraspecies

homolog to ATP1B and ATP4B,structural

Homologene

FAMILY

Na+/K+ and H+/K+ ATPases beta chain proteins family

CATEGORY

enzyme , transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
text	type 2 membrane protein

basic FUNCTION	osmotic balance and cell volume stability
	catalyzing the hydrolysis of ATP coupled
	with the exchange of Na(+) and K(+) ions across the plasma membrane

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

active transport

text	Na+, K+ pump

PATHWAY

metabolism

signaling

a component	complexing with ATP1A3 and maybe others
	two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta)

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP

protein

binding to ATP1A3

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS