Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

POU3F3

contributors: mct/npt - updated : 11-09-2019

HGNC name	POU class 3 homeobox 3
HGNC id	9216

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

NDDEA

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in esophageal squamous-cell carcinomas tumoral       gain of function in glioma tissue and significantly correlated with the advanced tumor stage

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive liver potential therapeutic strategy for hepatocellular carcinoma patients cancer brain   function as a putative therapeutic target in glioma

ANIMAL & CELL MODELS

	knock-out Brn1 mouse
	deficiency of Pou3f3 in knock-out mice leads to underdevelopment of the TAL, lack of differentiation of TAL cells, and perinatal death due to renal failure