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FLASH GENE
Symbol POU3F3 contributors: mct/npt - updated : 11-09-2019
HGNC name POU class 3 homeobox 3
HGNC id 9216
ASSOCIATED DISORDERS
corresponding disease(s) NDDEA
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in esophageal squamous-cell carcinomas
tumoral       gain of function
in glioma tissue and significantly correlated with the advanced tumor stage
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerdigestiveliver
potential therapeutic strategy for hepatocellular carcinoma patients
cancerbrain 
function as a putative therapeutic target in glioma
ANIMAL & CELL MODELS
  • knock-out Brn1 mouse
  • deficiency of Pou3f3 in knock-out mice leads to underdevelopment of the TAL, lack of differentiation of TAL cells, and perinatal death due to renal failure