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FLASH GENE

Symbol

POU3F3

contributors: mct/npt - updated : 11-09-2019

HGNC name	POU class 3 homeobox 3
HGNC id	9216

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	POU homeo (helix-turn-helix) domains, required for high affinity binding to octamer DNA sequences
	a homeobox DNA-binding domain

mono polymer

homomer , heteromer , dimer

HOMOLOGY

interspecies	homolog to murine Pou3f3/Brn1
	homolog to rattus Pou3f3
	homolog to C.elegans k02b12.1

intraspecies

paralog to POU3F2

Homologene

FAMILY

class III POU homeodomain family of transcription factors

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	having a transcription factor activity
	expression of SOX11 and POU3F3 may be modulated by the cell-type specific machinery
	may be important for the maintenance or functional development of the postnatal cochlea
	POU3F3 and POU3F2 (Brn1 and Brn2) are known to label postmitotic upper-layer cells, and are redundantly required for their production
	critically involved in development of distinct nephron segments, including the thick ascending limb of the loop of Henle (TAL)
	plays an oncogenic role in hepatocellular carcinoma
	share important roles in neurodevelopment with its close paralog POU3F2
	transcription factor involved in the development of the central nervous system, with essential functions for normal brain development

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

development , nervous system

text	playing a role in neurogenesis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding to the octamer motif ATGCAAAT

RNA

small molecule

protein	POU3F2, POU3F3 influence multiple stages of neurogenesis by suppressing Notch effector HES5, and promoting the expression of proneural transcription factors EOMES and TBR1
	contributes to the development of esophageal squamous cell carcinoma (ESCC) by interacting with EZH2 to promote methylation of POU3F3, which encodes a transcription factor
	may promote cancer cell proliferation in prostate carcinoma by upregulating ROCK1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

NDDEA

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in esophageal squamous-cell carcinomas tumoral       gain of function in glioma tissue and significantly correlated with the advanced tumor stage

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive liver potential therapeutic strategy for hepatocellular carcinoma patients cancer brain   function as a putative therapeutic target in glioma

ANIMAL & CELL MODELS

	knock-out Brn1 mouse
	deficiency of Pou3f3 in knock-out mice leads to underdevelopment of the TAL, lack of differentiation of TAL cells, and perinatal death due to renal failure