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FLASH GENE

Symbol

CD55

contributors: mct - updated : 20-10-2012

HGNC name	CD55 molecule, decay accelerating factor for complement (Cromer blood group)
HGNC id	2665

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CBGI

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in red blood cells from patients with paroxismal nocturne hemoglobinuria tumoral     --over   in colorectal cancer, and in rectal tumor tissues ( tumoral     --over   in primary gallbladder carcinoma constitutional     --over   in red blood cells from patients with aplastic anemia constitutional     --low   on peripheral blood leucocytes in T2DM patients with macrovascular diseases

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	elevated leukocyte CD55 may be a useful predictor of subsequent preterm labor/birth
Therapy target
	System Type Disorder Pubmed neurology acquired   augmenting its expression levels could be effective therapeutically in treating multiple sclerosis as well as other T cell mediated diseases

ANIMAL & CELL MODELS

Cd55-deficient mice display a phenotype with about two-fold more circulating granulocytes in the blood stream, the marginated pool, and the spleen