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FLASH GENE
Symbol CD55 contributors: mct - updated : 20-10-2012
HGNC name CD55 molecule, decay accelerating factor for complement (Cromer blood group)
HGNC id 2665
ASSOCIATED DISORDERS
corresponding disease(s) CBGI
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
in red blood cells from patients with paroxismal nocturne hemoglobinuria
tumoral     --over  
in colorectal cancer, and in rectal tumor tissues (
tumoral     --over  
in primary gallbladder carcinoma
constitutional     --over  
in red blood cells from patients with aplastic anemia
constitutional     --low  
on peripheral blood leucocytes in T2DM patients with macrovascular diseases
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • elevated leukocyte CD55 may be a useful predictor of subsequent preterm labor/birth
  • Therapy target
    SystemTypeDisorderPubmed
    neurologyacquired 
    augmenting its expression levels could be effective therapeutically in treating multiple sclerosis as well as other T cell mediated diseases
    ANIMAL & CELL MODELS
  • Cd55-deficient mice display a phenotype with about two-fold more circulating granulocytes in the blood stream, the marginated pool, and the spleen