Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

PAK1

contributors: mct/npt/pgu - updated : 27-09-2019

HGNC name	p21 protein (Cdc42/Rac)-activated kinase 1
HGNC id	8590

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MCSZ2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function in breast cancer tumoral     --over   in ovarian, breast, and bladder cancers

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology     may serve as a useful therapeutic target in NF2 cancer reproductive breast PAK1-directed therapy in breast cancer cancer lung   evidence for potential antitumor efficacy of PAK1 inhibition in squamous nonsmall cell lung carcinomas

ANIMAL & CELL MODELS