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FLASH GENE
Symbol PAK1 contributors: mct/npt/pgu - updated : 27-09-2016
HGNC name p21 protein (Cdc42/Rac)-activated kinase 1
HGNC id 8590
ASSOCIATED DISORDERS
corresponding disease(s) MCSZ2
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral       gain of function
in breast cancer
tumoral     --over  
in ovarian, breast, and bladder cancers
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
neurology  
may serve as a useful therapeutic target in NF2
cancerreproductivebreast
PAK1-directed therapy in breast cancer
cancerlung 
evidence for potential antitumor efficacy of PAK1 inhibition in squamous nonsmall cell lung carcinomas
ANIMAL & CELL MODELS