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FLASH GENE
Symbol ANXA11 contributors: mct/npt - updated : 10-07-2018
HGNC name annexin A11
HGNC id 535
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a relatively long N terminus
  • a C terminal "core" region made of four repeats homolog to the endonexin fold
  • the calcium-dependent phospholipid binding sites
    • HOMOLOGY
    interspecies homolog to murine Anxa11
    homolog to C.elegans To7c4.9
    Homologene
    FAMILY
  • annexin family of calcium dependent phospholipid-binding proteins
    • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm
    intracellular,nuclear envelope
    text cytoplasmic and possibly nuclear
    basic FUNCTION
  • calcium and phospholipid binding protein
  • playing an essential role in the terminal phase of cytokinesis
  • has complex and essential functions in several biological pathways, including apoptosis and proliferation
  • essential role for annexin 11 in the terminal phase of cytokinesis
  • plays an important role in cell division, Ca(2+) signaling, vesicle trafficking and apoptosis
  • ANXA11 maintains architectural and functional features of the ERES by coordinating with PDCD6 to stabilize SEC31A at the ER exit sites (ERES)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • phospholipids
  • Ca2+
    • protein
  • calcyclin associated
  • PDCD6-binding partner (the N-terminal regulatory domain of ANXA11) and the PDCD6-binding domain of Alix/AIP1 are rich in Pro, Gly, Ala, Tyr and Gln)
  • ANXA11, physically associates with SEC31A by the adaptor function of PDCD6
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ALS23
    Susceptibility to sarcoidosis
    Variant & Polymorphism SNP SNP (rs1049550, T > C, R230C) was found to be strongly associated with sarcoidosis
    Candidate gene
    Marker
  • is a promising biomarker for the diagnosis, treatment and prognosis of certain diseases
    • Therapy target
    ANIMAL & CELL MODELS